[Pathological Complete Response after Combined Chemotherapy of Durvalumab, Gemcitabine and Cisplatin for Intrahepatic Cholangiocarcinoma-A Case Report].

Abstract

The patient was a 66-year-old man. He came to our hospital because of abdominal discomfort. A CT scan revealed hypovascular tumors of about 70 mm in the S4/5 and 16 mm in the S6 of the liver. The S4/5 tumor was directly invasive into the greater omentum and abdominal wall, and a nodule suspected of peritoneal dissemination was observed around the tumor. Based on tumor biopsy results, a diagnosis of intrahepatic cholangiocarcinoma(ICC), cT3N0M1, Stage ⅣB was made. A total of 9 courses of GCD therapy(gemcitabine+cisplatin+durvalumab)were performed for ICC and the tumor was found to have shrunk, and the S6 tumor was obscured. The FDG-PET/CT scan also showed similar results, and the patient was judged to be curative, and surgery was performed 8 months after the initial diagnosis. Laparoscopic hepatic S4a/5 subsegmentectomy and S6 partial hepatectomy were performed. Intraoperative findings showed no peritoneal dissemination, and cytology of washed ascites was negative. Histopathological examination did not reveal any tumor cells, and the patient was judged to have a pathological complete response(pCR). There are few reports of ICC with pCR after GCD therapy, and we report this case here with a review of the literature.