Successful management of severe coagulopathy in a dog following Cerastes gasperettii (Arabian horned Viper) envenomation: First clinical case description in Israel

IF 2.6 4区医学 Q2 PHARMACOLOGY & PHARMACY

Toxicon Pub Date : 2025-03-10 DOI:10.1016/j.toxicon.2025.108321

Green Iris , Kelmer Efrat , Mazon Yael , Aroch Itamar , Klainbart Sigal

引用次数: 0

Abstract

This report describes the first documented clinical case of a confirmed, naturally occurring Cerastes gasperettii (C. gasperettii; Arabian horned viper) envenomation, providing valuable insight into the limited literature on this important species. The case describes a five-year-old pointer dog from the Arave Valley, Israel. Clinical signs included progressive soft tissue swelling and lethargy. Laboratory findings revealed severe coagulopathy, mild renal impairment, and evidence of microangiopathic hemolysis. Despite the unavailability of species-specific antivenom, treatment management with canine fresh frozen plasma, crystalloid therapy, and supportive care, resulted in full recovery within 36 hours. This case contributes significantly to understanding the clinical manifestations, therapeutic strategies, and potential pathophysiological mechanisms of C. gasperettii envenomation.

Abstract Image

查看原文本刊更多论文

成功的管理严重凝血病的狗后cerastasperettii（阿拉伯角毒蛇）中毒：第一个临床病例描述在以色列。

本报告描述了确诊的自然发生的gasperettii (C. gasperettii；阿拉伯角蝰)中毒，提供有价值的见解，对这一重要物种的有限文献。该病例描述了一只来自以色列阿拉韦山谷的五岁大的指示犬。临床表现为进行性软组织肿胀和嗜睡。实验室结果显示严重的凝血功能障碍，轻度肾功能损害和微血管病溶血的证据。尽管无法获得特定种类的抗蛇毒血清，但通过犬新鲜冷冻血浆、晶体治疗和支持性护理，在36小时内完全康复。本病例对了解猪链球菌中毒的临床表现、治疗策略及潜在的病理生理机制具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Toxicon 医学-毒理学

CiteScore

4.80

自引率

10.70%

发文量

358

审稿时长

68 days

期刊介绍： Toxicon has an open access mirror Toxicon: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. An introductory offer Toxicon: X - full waiver of the Open Access fee. Toxicon''s "aims and scope" are to publish: -articles containing the results of original research on problems related to toxins derived from animals, plants and microorganisms -papers on novel findings related to the chemical, pharmacological, toxicological, and immunological properties of natural toxins -molecular biological studies of toxins and other genes from poisonous and venomous organisms that advance understanding of the role or function of toxins -clinical observations on poisoning and envenoming where a new therapeutic principle has been proposed or a decidedly superior clinical result has been obtained. -material on the use of toxins as tools in studying biological processes and material on subjects related to venom and antivenom problems. -articles on the translational application of toxins, for example as drugs and insecticides -epidemiological studies on envenoming or poisoning, so long as they highlight a previously unrecognised medical problem or provide insight into the prevention or medical treatment of envenoming or poisoning. Retrospective surveys of hospital records, especially those lacking species identification, will not be considered for publication. Properly designed prospective community-based surveys are strongly encouraged. -articles describing well-known activities of venoms, such as antibacterial, anticancer, and analgesic activities of arachnid venoms, without any attempt to define the mechanism of action or purify the active component, will not be considered for publication in Toxicon. -review articles on problems related to toxinology. To encourage the exchange of ideas, sections of the journal may be devoted to Short Communications, Letters to the Editor and activities of the affiliated societies.