Comparative analysis of alpha-fetoprotein, carbohydrate antigen 19-9, carcinoembryonic antigen, and prostate-specific antigen among conventional cigarette smokers, heated tobacco product users and quitters.

IF 2.2 4区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Tobacco Induced Diseases Pub Date : 2025-03-12 eCollection Date: 2025-01-01 DOI:10.18332/tid/200890

Dae-Hyun Kim, Seung-Wan Hong, Naeun Park

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引用次数: 0

Abstract

Introduction: The association of Heated Tobacco Products (HTPs) use on cancer-related biomarkers remains unclear. This study aimed to compare the levels of tumor markers, specifically alpha-fetoprotein (AFP), carbohydrate antigen 19-9 (CA 19-9), carcinoembryonic antigen (CEA), and prostate-specific antigen (PSA), between combustible cigarette (CC) smokers, any HTP users, and quitters.

Methods: This cross-sectional study compared tumor marker levels (AFP, CA 19-9, CEA, PSA) among 750 adult males: 250 CC smokers, 250 any HTP users, and 250 quitters. Data were collected from health screenings (2021-2022). Participants were aged >18 years with at least one year of smoking history.

Results: CEA was significantly higher in CC smokers (median: 2.4) than any HTP users (median: 2.0) and quitters (median: 1.6), with any HTP users exceeding quitters. PSA was higher in any HTP users (median: 0.86) than quitters (median: 0.74). No significant differences were observed in AFP and CA 19-9.

Conclusions: HTP users exhibit lower CEA levels compared to conventional cigarette smokers, yet their levels remain higher than those of quitters. Additionally, quitters were found to have lower PSA levels than HTP users. Further research is needed to determine the reasons for these differences.

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甲胎蛋白、碳水化合物抗原19-9、癌胚抗原和前列腺特异性抗原在常规吸烟者、加热烟草制品使用者和戒烟者中的比较分析

导读：加热烟草制品（HTPs）与癌症相关生物标志物的关联尚不清楚。本研究旨在比较可燃香烟（CC）吸烟者、任何HTP使用者和戒烟者之间的肿瘤标志物水平，特别是甲胎蛋白（AFP）、碳水化合物抗原19-9 （CA 19-9）、癌胚抗原（CEA）和前列腺特异性抗原（PSA）。方法：本横断面研究比较了750名成年男性的肿瘤标志物水平（AFP, ca19 -9， CEA， PSA）： 250名CC吸烟者，250名任何HTP使用者和250名戒烟者。数据收集自健康筛查（2021-2022年）。参与者年龄在18到18岁之间，至少有一年的吸烟史。结果：CC吸烟者的CEA（中位数：2.4）明显高于任何HTP使用者（中位数：2.0）和戒烟者（中位数：1.6），任何HTP使用者都超过戒烟者。任何HTP使用者的PSA（中位数：0.86）都高于戒烟者（中位数：0.74）。AFP和ca19 -9无显著性差异。结论：与传统吸烟者相比，HTP使用者的CEA水平较低，但其水平仍高于戒烟者。此外，戒烟者的PSA水平低于HTP使用者。需要进一步的研究来确定这些差异的原因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tobacco Induced Diseases SUBSTANCE ABUSE-PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

CiteScore

5.30

自引率

5.40%

发文量

审稿时长

12 weeks

期刊介绍： Tobacco Induced Diseases encompasses all aspects of research related to the prevention and control of tobacco use at a global level. Preventing diseases attributable to tobacco is only one aspect of the journal, whose overall scope is to provide a forum for the publication of research articles that can contribute to reducing the burden of tobacco induced diseases globally. To address this epidemic we believe that there must be an avenue for the publication of research/policy activities on tobacco control initiatives that may be very important at a regional and national level. This approach provides a very important "hands on" service to the tobacco control community at a global scale - as common problems have common solutions. Hence, we see ourselves as "connectors" within this global community. The journal hence encourages the submission of articles from all medical, biological and psychosocial disciplines, ranging from medical and dental clinicians, through health professionals to basic biomedical and clinical scientists.