Regional variations in corneal oedema during open-eye fenestrated scleral lens wear.

IF 2.8 3区 医学 Q1 OPHTHALMOLOGY
Ophthalmic and Physiological Optics Pub Date : 2025-05-01 Epub Date: 2025-03-13 DOI:10.1111/opo.13489
Asif Iqbal, Damien Fisher, David Alonso-Caneiro, Michael J Collins, Stephen J Vincent
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引用次数: 0

Abstract

Purpose: To compare the magnitude of central, mid-peripheral and peripheral stromal corneal oedema induced during short-term fenestrated and non-fenestrated scleral lens wear.

Methods: Nine healthy participants wore a non-fenestrated and a fenestrated (0.3-mm diameter limbal fenestration) scleral lens (KATT™, Capricornia Contact Lenses), hexafocon B material (Dk 141 × 10-11 cm3 O2(cm)/[(s) (cm2) (mmHg)]) in one eye under open-eye conditions for 90 min on two separate days. Scleral lens thickness, fluid reservoir thickness and stromal corneal oedema were measured using high-resolution optical coherence tomography. Stromal oedema was quantified across the central (0-2.5 mm from the corneal apex), mid-peripheral (-3.0 to -1.0 mm from the scleral spur) and peripheral (-1.0 to 0 mm from the scleral spur) cornea with the lens in situ. The magnitude of oedema was corrected based on variations in fluid reservoir thickness between the lens conditions.

Results: There was a significant effect of lens type (p = 0.04) on stromal oedema, with less oedema observed with the fenestrated (0.36 ± 0.45%) compared to the non-fenestrated lenses (1.24 ± 0.27%), averaged across all corneal locations. A significant lens type by corneal location interaction was also observed (p = 0.05), with less oedema observed in the peripheral region for the fenestrated (-0.15 ± 0.98%) compared to the non-fenestrated lenses (1.81 ± 0.57%) (p = 0.048). A fenestration location by corneal location interaction was also observed (p = 0.02), indicating a greater reduction in oedema closer to the fenestration.

Conclusions: Central and mid-peripheral stromal oedema was similar during fenestrated and non-fenestrated lens wear; however, fenestrated lenses displayed significantly less oedema in the peripheral cornea. This is most likely due to increased oxygen delivery in proximity to the fenestration.

开窗巩膜晶状体佩戴期间角膜水肿的区域差异。
目的:比较有孔和无孔巩膜晶状体短期配戴时中央、中外周和外周角膜间质水肿的程度。方法:9名健康参与者分别在两天的裸眼条件下,在一只眼睛上佩戴非开窗和开窗(0.3 mm直径的角膜缘开窗)巩膜镜片(KATT™,Capricornia隐形眼镜),六焦锥B材料(Dk 141 × 10-11 cm3 O2(cm)/[(s) (cm2) (mmHg)]) 90分钟。采用高分辨率光学相干断层扫描测量巩膜晶状体厚度、储液层厚度和角膜间质水肿。在晶状体原位的情况下,对中央(距角膜顶点0-2.5 mm)、中外周(距巩膜骨刺-3.0至-1.0 mm)和外周(距巩膜骨刺-1.0至0 mm)角膜的间质水肿进行量化。根据晶状体条件下流体储层厚度的变化,对水肿程度进行了校正。结果:晶状体类型对角膜间质水肿有显著影响(p = 0.04),在角膜各部位的平均值中,有开窗晶状体的水肿(0.36±0.45%)比无开窗晶状体的水肿(1.24±0.27%)少。角膜位置相互作用对晶状体类型也有显著影响(p = 0.05),与非开窗晶状体相比,开窗晶状体外周区水肿较少(-0.15±0.98%)(1.81±0.57%)(p = 0.048)。通过角膜位置相互作用也观察到开窗位置(p = 0.02),表明靠近开窗的水肿减少更大。结论:有孔晶状体和无孔晶状体磨损时,中央和中外周间质水肿相似;然而,开窗晶状体在周围角膜的水肿明显较少。这很可能是由于靠近开窗的氧气输送增加。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.10
自引率
13.80%
发文量
135
审稿时长
6-12 weeks
期刊介绍: Ophthalmic & Physiological Optics, first published in 1925, is a leading international interdisciplinary journal that addresses basic and applied questions pertinent to contemporary research in vision science and optometry. OPO publishes original research papers, technical notes, reviews and letters and will interest researchers, educators and clinicians concerned with the development, use and restoration of vision.
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