The Natural History of Pediatric Cerebellopontine Angle Lipomas.

IF 1.9 3区 医学 Q3 CLINICAL NEUROLOGY
Otology & Neurotology Pub Date : 2025-04-01 Epub Date: 2025-02-10 DOI:10.1097/MAO.0000000000004433
Ruth K Mizu, Benjamin D Lovin, Caitlin M Coviello, Guillermo Aldave Orzaiz, Akash J Patel, Alex D Sweeney
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引用次数: 0

Abstract

Objective: To present a series of pediatric patients with cerebellopontine angle (CPA) lipomas in order to understand their natural history and facilitate management recommendations.

Patients: Pediatric patients with a diagnosis of CPA lipoma.

Interventions: Clinical data collected from a single tertiary care center between January 2000 and August 2022.

Main outcome measures: Data related to symptom evolution and tumor growth during follow-up.

Results: Six patients were identified from a single institution. Average age at presentation was 8.5 years of age (range, 3.1-14.5 years). The most common presenting symptoms were headaches (63%) followed by sensorineural hearing loss (SNHL) (38%). Average tumor size was 10.8 mm (range, 5.8-18 mm). Average duration of clinic and radiographic follow-up were 61 months (range, 16.9-146.1 months) and 52 months (range, 8.7-133.2 months), respectively. Other than 1 patient who experienced worsening asymmetric SNHL, no patient experienced significant changes in symptoms or tumor growth throughout follow-up. On most recent imaging, the average tumor size was 11.3 mm (range, 7-21 mm), which was not statistically different from initial imaging (p = 0.518).

Conclusions: Pediatric CPA lipomas represent a rare entity of lateral skull base tumors. Most patients present with headaches and SNHL in the adolescent age. While progression of SNHL and tumor growth is possible, most patients do not appear to demonstrate worsening symptoms or tumor growth throughout follow-up. As such, initial management with serial MRI appears to be a safe strategy.

小儿桥小脑角脂肪瘤的自然史。
目的:介绍一系列小儿桥小脑角(CPA)脂肪瘤的病例,了解其自然病史并提出治疗建议。患者:诊断为CPA脂肪瘤的儿科患者。干预措施:2000年1月至2022年8月期间从单一三级保健中心收集的临床数据。主要观察指标:随访期间症状演变及肿瘤生长相关数据。结果:6例患者来自同一机构。平均发病年龄为8.5岁(范围3.1-14.5岁)。最常见的症状是头痛(63%),其次是感音神经性听力损失(SNHL)(38%)。平均肿瘤大小为10.8 mm(范围为5.8-18 mm)。平均临床随访61个月(16.9 ~ 146.1个月),平均影像学随访52个月(8.7 ~ 133.2个月)。除1例患者出现不对称SNHL恶化外,随访期间没有患者出现明显的症状或肿瘤生长变化。在最近的影像学中,平均肿瘤大小为11.3 mm(范围7-21 mm),与初始影像学无统计学差异(p = 0.518)。结论:儿童CPA脂肪瘤是一种罕见的颅底外侧肿瘤。大多数患者在青少年时期出现头痛和SNHL。虽然SNHL的进展和肿瘤生长是可能的,但在整个随访过程中,大多数患者似乎没有表现出症状恶化或肿瘤生长。因此,用连续MRI进行初始治疗似乎是一种安全的策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Otology & Neurotology
Otology & Neurotology 医学-耳鼻喉科学
CiteScore
3.80
自引率
14.30%
发文量
509
审稿时长
3-6 weeks
期刊介绍: ​​​​​Otology & Neurotology publishes original articles relating to both clinical and basic science aspects of otology, neurotology, and cranial base surgery. As the foremost journal in its field, it has become the favored place for publishing the best of new science relating to the human ear and its diseases. The broadly international character of its contributing authors, editorial board, and readership provides the Journal its decidedly global perspective.
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