Vitality is associated with systemic inflammation in cystic fibrosis adults on elexacaftor/tezacaftor/ivacaftor.

IF 5.4 2区 医学 Q1 RESPIRATORY SYSTEM
Jacob Gravelle, Sameer Desai, Kang Dong, Bradley S Quon
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引用次数: 0

Abstract

Fatigue is common among adults with cystic fibrosis (awCF) and may be associated with systemic inflammation. This study examines systemic inflammation, measured by C-reactive protein (CRP), and fatigue, assessed using the Cystic Fibrosis Questionnaire-Revised (CFQ-R) vitality domain, in individuals initiating elexacaftor/tezacaftor/ivacaftor (ETI) therapy. In a cohort of 61 awCF from St. Paul's Hospital, Vancouver, CRP and vitality were measured at baseline and at 1, 3, 6, and 12 months post-ETI initiation. We observed reductions in CRP and increases in vitality over the 12-month period. Linear mixed-effects models were used to examine the relationship between CRP and vitality adjusted for age, sex, BMI, and lung function. Our findings demonstrated a significant, independent inverse association between CRP and vitality. These results highlight the potential role of systemic inflammation in influencing vitality in awCF undergoing ETI therapy. Further research incorporating additional inflammatory markers and psychosocial variables is warranted to deepen our understanding of fatigue mechanisms in this population.

囊性纤维化成人服用elexaftor /tezacaftor/ivacaftor时,活力与全身性炎症相关。
疲劳在患有囊性纤维化(awCF)的成年人中很常见,可能与全身炎症有关。本研究检查了在开始elexaftor /tezacaftor/ivacaftor (ETI)治疗的个体中,通过c反应蛋白(CRP)测量的全身炎症和疲劳,使用囊性纤维化问卷-修订(CFQ-R)活力域进行评估。在温哥华圣保罗医院的61例awCF队列中,在基线和eti开始后1、3、6和12个月测量CRP和活力。在12个月的时间里,我们观察到CRP的减少和活力的增加。使用线性混合效应模型来检验CRP与活力之间的关系,并根据年龄、性别、BMI和肺功能进行调整。我们的发现证明了CRP和活力之间显著的、独立的负相关关系。这些结果强调了全身性炎症在影响接受ETI治疗的awCF活力中的潜在作用。进一步的研究纳入额外的炎症标志物和社会心理变量是必要的,以加深我们对这一人群疲劳机制的理解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Cystic Fibrosis
Journal of Cystic Fibrosis 医学-呼吸系统
CiteScore
10.10
自引率
13.50%
发文量
1361
审稿时长
50 days
期刊介绍: The Journal of Cystic Fibrosis is the official journal of the European Cystic Fibrosis Society. The journal is devoted to promoting the research and treatment of cystic fibrosis. To this end the journal publishes original scientific articles, editorials, case reports, short communications and other information relevant to cystic fibrosis. The journal also publishes news and articles concerning the activities and policies of the ECFS as well as those of other societies related the ECFS.
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