Split-brain patients: A clinical vs experimental perspective.

Q2 Medicine

Handbook of clinical neurology Pub Date : 2025-01-01 DOI:10.1016/B978-0-443-15646-5.00015-4

Michael B Miller, Lukas J Volz, Jessica M Simonson, Michael S Gazzaniga

引用次数: 0

Abstract

For more than 80 years, the clinical perspective on the behavioral outcome of split-brain surgery suggested that it "may be carried out without any untoward effect on the patient," despite some initial and transient disconnection effects. The last 60 years of experimental studies, however, have shown quite the opposite. Using lateralized testing procedures, split-brain patients have demonstrated profound disconnection effects that can last a lifetime. This experimental work has transformed our understanding of hemispheric specializations and cerebral asymmetries. It paints a picture of patients with two distinct neural systems processing and operating independently with, nevertheless, a seemingly unified conscious experience. This chapter tracks how these two divergent perspectives have coexisted for so long and offers some explanations for why these patients appear normal from a clinical and social perspective.

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来源期刊

Handbook of clinical neurology Medicine-Neurology (clinical)

CiteScore

4.10

自引率

0.00%

发文量

302

期刊介绍： The Handbook of Clinical Neurology (HCN) was originally conceived and edited by Pierre Vinken and George Bruyn as a prestigious, multivolume reference work that would cover all the disorders encountered by clinicians and researchers engaged in neurology and allied fields. The first series of the Handbook (Volumes 1-44) was published between 1968 and 1982 and was followed by a second series (Volumes 45-78), guided by the same editors, which concluded in 2002. By that time, the Handbook had come to represent one of the largest scientific works ever published. In 2002, Professors Michael J. Aminoff, François Boller, and Dick F. Swaab took on the responsibility of supervising the third (current) series, the first volumes of which published in 2003. They have designed this series to encompass both clinical neurology and also the basic and clinical neurosciences that are its underpinning. Given the enormity and complexity of the accumulating literature, it is almost impossible to keep abreast of developments in the field, thus providing the raison d''être for the series. The series will thus appeal to clinicians and investigators alike, providing to each an added dimension. Now, more than 140 volumes after it began, the Handbook of Clinical Neurology series has an unparalleled reputation for providing the latest information on fundamental research on the operation of the nervous system in health and disease, comprehensive clinical information on neurological and related disorders, and up-to-date treatment protocols.