Latent dimensions of brain asymmetry.

Abstract

Functional lateralization represents a fundamental aspect of brain organization, where certain cognitive functions are specialized in one hemisphere over the other. Deviations from typical patterns of lateralization often manifest in various brain disorders, such as autism spectrum disorder, schizophrenia, and dyslexia. However, despite its importance, uncovering the intrinsic properties of brain lateralization and its underlying structural basis remains challenging. On the one hand, functional lateralization has long been oversimplified, often reduced to a unidimensional perspective. For instance, individuals are sometimes labeled as left-brained or right-brained based on specific behavioral measures like handedness and language lateralization. Such a perspective disregards the nuanced subtypes of lateralization, each potentially attributed to distinct factors and associated with unique functional correlates. On the other hand, traditional studies of brain structural asymmetry have typically focused on localized analyses of homologous regions in the two hemispheres. This perspective fails to capture the inherent interplay between brain regions, resulting in an overly complex depiction of structural asymmetry. Such conceptual and methodological discrepancies between studies of functional lateralization and structural asymmetry pose significant obstacles to establishing meaningful links between them. To address this gap, a shift toward uncovering the dimensional structure of brain asymmetry has been proposed. This chapter introduces the concept of latent dimensions of brain asymmetry and provides an up-to-date overview of studies regarding dimensions of functional lateralization and structural asymmetry in the human brain. By transcending the traditional analysis and employing multivariate pattern techniques, these studies offer valuable insights into our understanding of the intricate organizational principles governing the human brain's lateralized functions.