Hemispheric organization of the brain and its prevailing impact on the neuropsychology of aging.

Q2 Medicine

Handbook of clinical neurology Pub Date : 2025-01-01 DOI:10.1016/B978-0-443-15646-5.00004-X

Sara B Festini, Grace Kegler, Patricia A Reuter-Lorenz

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Abstract

Age differences in brain hemispheric asymmetry have figured prominently in the neuropsychology of aging. Here, a broad overview of these empirical and theoretical approaches is provided that dates back to the 1970s and continues to the present day. Methodological advances often brought new evidence to bear on older ideas and promoted the development of new ones. The deficit-focused hypothesis of accelerated right-hemisphere aging is reviewed first, followed by subsequent accounts pertaining to compensation, reserve, and their potential hemispheric underpinnings. Structural and functional neuroimaging reveal important and consistent age-related patterns, including indications of reduced brain asymmetry in older relative to younger adults. While not mutually exclusive, different neuropsychologic theories of aging offer divergent interpretations of such patterns, including age-related reductions in neural specificity (dedifferentiation) and age-related compensatory bilateral recruitment [e.g., Hemispheric Asymmetry Reduction in Older Adults (HAROLD); Compensation-Related Utilization of Neural Circuits Hypothesis (CRUNCH)]. Further, recent neurobehavioral evidence suggests that the right hemisphere plays a unique role in resisting the neurocognitive effects of aging via brain reserve. Future advances in human cognitive neuroscience, including neurostimulation methods for targeted interventions, along with analytic techniques informed by machine learning promise new insights into the neuropsychology of aging and the role of hemispheric processes in resilience and decline.

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来源期刊

Handbook of clinical neurology Medicine-Neurology (clinical)

CiteScore

4.10

自引率

0.00%

发文量

302

期刊介绍： The Handbook of Clinical Neurology (HCN) was originally conceived and edited by Pierre Vinken and George Bruyn as a prestigious, multivolume reference work that would cover all the disorders encountered by clinicians and researchers engaged in neurology and allied fields. The first series of the Handbook (Volumes 1-44) was published between 1968 and 1982 and was followed by a second series (Volumes 45-78), guided by the same editors, which concluded in 2002. By that time, the Handbook had come to represent one of the largest scientific works ever published. In 2002, Professors Michael J. Aminoff, François Boller, and Dick F. Swaab took on the responsibility of supervising the third (current) series, the first volumes of which published in 2003. They have designed this series to encompass both clinical neurology and also the basic and clinical neurosciences that are its underpinning. Given the enormity and complexity of the accumulating literature, it is almost impossible to keep abreast of developments in the field, thus providing the raison d''être for the series. The series will thus appeal to clinicians and investigators alike, providing to each an added dimension. Now, more than 140 volumes after it began, the Handbook of Clinical Neurology series has an unparalleled reputation for providing the latest information on fundamental research on the operation of the nervous system in health and disease, comprehensive clinical information on neurological and related disorders, and up-to-date treatment protocols.