TRP channels and breast cancer: the role of TRPs in the pathophysiological development.

IF 3.9 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Frontiers in Molecular Biosciences Pub Date : 2025-02-26 eCollection Date: 2025-01-01 DOI:10.3389/fmolb.2025.1528663

Yu Zhang, Yanfeng Yi, Yinghao Shu, Xiaochen Ru, Shuaibing He

引用次数: 0

Abstract

TRP channels play important roles in regulating various physiological and pathological processes, including the progression of cancer. Several TRP channels mediate tumour development. This review focuses on the role of TRP channels in the development of breast cancer, including their involvement in proliferation, apoptosis, autophagy, metastasis, and angiogenesis. TRP channels are associated with breast carcinogenesis and their role as potential therapeutic targets and prognostic biomarkers is under investigation. This review summarizes the reported effects of inhibiting or agonizing various TRP channel in breast cancer cells. Although there are relatively mature protocols for the treatment of breast cancer, its treatment is not currently a breakthrough, and therapies targeting TRP channels may be a developable strategy for it.

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TRP通道与乳腺癌：TRP在病理生理发展中的作用。

TRP通道在调节各种生理和病理过程中发挥重要作用，包括癌症的进展。几个TRP通道介导肿瘤的发展。本文综述了TRP通道在乳腺癌发生发展中的作用，包括它们在增殖、凋亡、自噬、转移和血管生成中的作用。TRP通道与乳腺癌发生有关，其作为潜在治疗靶点和预后生物标志物的作用正在研究中。本文综述了抑制或诱导多种TRP通道在乳腺癌细胞中的作用。虽然乳腺癌的治疗方案相对成熟，但目前其治疗还不是一个突破，针对TRP通道的治疗可能是一个可发展的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Molecular Biosciences Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

7.20

自引率

4.00%

发文量

1361

审稿时长

14 weeks

期刊介绍： Much of contemporary investigation in the life sciences is devoted to the molecular-scale understanding of the relationships between genes and the environment — in particular, dynamic alterations in the levels, modifications, and interactions of cellular effectors, including proteins. Frontiers in Molecular Biosciences offers an international publication platform for basic as well as applied research; we encourage contributions spanning both established and emerging areas of biology. To this end, the journal draws from empirical disciplines such as structural biology, enzymology, biochemistry, and biophysics, capitalizing as well on the technological advancements that have enabled metabolomics and proteomics measurements in massively parallel throughput, and the development of robust and innovative computational biology strategies. We also recognize influences from medicine and technology, welcoming studies in molecular genetics, molecular diagnostics and therapeutics, and nanotechnology. Our ultimate objective is the comprehensive illustration of the molecular mechanisms regulating proteins, nucleic acids, carbohydrates, lipids, and small metabolites in organisms across all branches of life. In addition to interesting new findings, techniques, and applications, Frontiers in Molecular Biosciences will consider new testable hypotheses to inspire different perspectives and stimulate scientific dialogue. The integration of in silico, in vitro, and in vivo approaches will benefit endeavors across all domains of the life sciences.