L-serine metabolic regulation and host respiratory homeostasis.

IF 4.8 2区医学 Q2 IMMUNOLOGY

Frontiers in Cellular and Infection Microbiology Pub Date : 2025-02-26 eCollection Date: 2025-01-01 DOI:10.3389/fcimb.2025.1518659

Pan Li, Xiaoyan Wu, Yanlan Huang, Ruijing Qin, Pan Xiong, Yangyang Qiu

引用次数: 0

Abstract

L-Serine, a non-essential amino acid (NEAA), can be obtained through diet or in situ synthesis. Functionally, L-serine not only serves as the precursor of other amino acids, lipids, and nucleotides, but also participates in the folate/methionine cycle. An increasing number of studies have demonstrated that L-serine is widely used in the adjuvant therapy of many diseases (e.g., inflammation, infections, fibrosis, and tumors). Here, we summarize the synthesis and metabolism of serine followed by its functions in health and disease. Moreover, we delineate the potential mechanisms whereby L-serine is involved in the occurrence and progression of respiratory diseases. This review aims to summarize the research progress of serine in diseases, propose the problems that need to be solved in the future, and provide guidance for subsequent research and development.

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l -丝氨酸代谢调节与宿主呼吸稳态。

l -丝氨酸是一种非必需氨基酸（NEAA），可通过日粮或原位合成获得。在功能上，l -丝氨酸不仅作为其他氨基酸、脂质和核苷酸的前体，而且还参与叶酸/蛋氨酸循环。越来越多的研究表明，l -丝氨酸广泛应用于多种疾病（如炎症、感染、纤维化、肿瘤等）的辅助治疗。本文综述了丝氨酸的合成和代谢，以及它在健康和疾病中的作用。此外，我们描述了l -丝氨酸参与呼吸系统疾病发生和发展的潜在机制。本文旨在总结丝氨酸在疾病中的研究进展，提出未来需要解决的问题，为后续的研究开发提供指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Cellular and Infection Microbiology IMMUNOLOGY-MICROBIOLOGY

CiteScore

7.90

自引率

7.00%

发文量

1817

审稿时长

14 weeks

期刊介绍： Frontiers in Cellular and Infection Microbiology is a leading specialty journal, publishing rigorously peer-reviewed research across all pathogenic microorganisms and their interaction with their hosts. Chief Editor Yousef Abu Kwaik, University of Louisville is supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Frontiers in Cellular and Infection Microbiology includes research on bacteria, fungi, parasites, viruses, endosymbionts, prions and all microbial pathogens as well as the microbiota and its effect on health and disease in various hosts. The research approaches include molecular microbiology, cellular microbiology, gene regulation, proteomics, signal transduction, pathogenic evolution, genomics, structural biology, and virulence factors as well as model hosts. Areas of research to counteract infectious agents by the host include the host innate and adaptive immune responses as well as metabolic restrictions to various pathogenic microorganisms, vaccine design and development against various pathogenic microorganisms, and the mechanisms of antibiotic resistance and its countermeasures.