Assessment of Risk of Malignancy by Application of the Proposed IAC–IARC–WHO Cytopathology System for Classification and Reporting of Soft Tissue Lesions: An Experience From Tertiary Care Center From India

IF 1 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY

Diagnostic Cytopathology Pub Date : 2025-03-13 DOI:10.1002/dc.25464

Mukund Sable, M. Shameema Farween, Pritinanda Mishra, Suvendu Purkait, Pavithra Ayyanar, Amit Kumar Adhya, Madhusmita Sethy, Susama Patra

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引用次数: 0

Abstract

Introduction

Soft tissue lesions encompass a diverse category of diseases from benign to malignant, and their morphology might overlap; therefore, accurate categorization is needed to approach the reporting of soft tissue cytology. The cytology of these lesions is helpful in detecting the features of malignancy, which helps in guiding further management. In this study, we applied the proposed IAC–IARC–WHO cytopathology system to assess the risk of malignancy (ROM) and diagnostic accuracy (DA) for the determination of its clinical and diagnostic utility.

Methods and Materials

This was a 5-year retrospective study of fine needle aspirations (FNA) of soft tissue, which were categorized according to the proposed IAC–IARC–WHO system. Cytological diagnoses were correlated with the corresponding histopathological diagnoses to assess diagnostic accuracy and ROM for each diagnostic category and to evaluate the diagnostic utility of FNAC by analyzing the sensitivity, specificity, and accuracy.

Results

A total of 1509 FNAC cases of soft tissue lesions were classified under the proposed six categories of the IAC–IARC–WHO system. Final histology was compared with cytology in 250 cases. Considering malignant diagnosis as a positive result, the overall sensitivity, specificity, and accuracy of FNAC were found to be 58.14%, 99.03%, and 92%, respectively. ROM was calculated in each category, which had a wide range from 7.6% to 100%.

Conclusion

We have validated the IAC–IARC–WHO system for soft tissue cytology and found it to be effective with the sensitivity and specificity results. FNA categorization is helpful for better communication between cytopathologists and clinicians, ensuring better reproducibility, which is crucial for guiding further diagnostic workup and surgical management.

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应用拟议的IAC-IARC-WHO细胞病理学系统进行软组织病变分类和报告的恶性肿瘤风险评估：来自印度三级保健中心的经验。

简介：软组织病变包括从良性到恶性的多种疾病，它们的形态可能重叠；因此，需要准确的分类来接近软组织细胞学报告。这些病变的细胞学检查有助于发现恶性肿瘤的特征，从而有助于指导进一步的治疗。在本研究中，我们应用提出的国际癌症研究中心-国际癌症研究中心-世界卫生组织细胞病理学系统来评估恶性肿瘤的风险（ROM）和诊断准确性（DA），以确定其临床和诊断效用。方法和材料：本研究是一项为期5年的软组织细针穿刺（FNA）回顾性研究，根据建议的IAC-IARC-WHO系统进行分类。细胞学诊断与相应的组织病理学诊断相关联，以评估每种诊断类别的诊断准确性和ROM，并通过分析敏感性、特异性和准确性来评估FNAC的诊断效用。结果：1509例FNAC软组织病变按提出的iarc - iarc - who六类分类体系进行分类。将250例患者的最终组织学与细胞学进行比较。以恶性诊断为阳性结果，FNAC的总体敏感性为58.14%，特异性为99.03%，准确性为92%。每个类别都计算了ROM，其范围从7.6%到100%不等。结论：本研究验证了IAC-IARC-WHO软组织细胞学检测系统的有效性，具有较高的灵敏度和特异性。FNA分类有助于细胞病理学家和临床医生之间更好的沟通，确保更好的重复性，这对指导进一步的诊断检查和手术处理至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diagnostic Cytopathology 医学-病理学

CiteScore

2.60

自引率

7.70%

发文量

163

审稿时长

3-6 weeks

期刊介绍： Diagnostic Cytopathology is intended to provide a forum for the exchange of information in the field of cytopathology, with special emphasis on the practical, clinical aspects of the discipline. The editors invite original scientific articles, as well as special review articles, feature articles, and letters to the editor, from laboratory professionals engaged in the practice of cytopathology. Manuscripts are accepted for publication on the basis of scientific merit, practical significance, and suitability for publication in a journal dedicated to this discipline. Original articles can be considered only with the understanding that they have never been published before and that they have not been submitted for simultaneous review to another publication.