Role of Protein Lysine Acetylation in the Pathogenesis and Treatment of Obesity and Metabolic Syndrome.

IF 9.5 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Current Obesity Reports Pub Date : 2025-03-13 DOI:10.1007/s13679-025-00615-1

Zhaopeng Li, Yancheng Song, Zhao Li, Shuguang Liu, Song Yi, Zhuoli Zhang, Tao Yu, Yu Li

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引用次数: 0

Abstract

Purpose of review: This review aimed to highlight the known role of histone deacetylases (HDACs) and lysine acetyltransferases (KATs) in individuals with obesity, better understand the role of HDACs and KATs enzymes in obesity and related metabolic disorders.

Recent findings: Numerous cellular activities, including DNA replication, DNA repair, cell cycle regulation, RNA splicing, signal transmission, metabolic function, protein stability, transportation, and transcriptional regulation, are influenced by lysine acetylation. Protein lysine acetylation serves several purposes, which not only contribute to the development of metabolic disorders linked to obesity but also hold promise for therapeutic approaches. The current study demonstrates that HDACs and KATs control lysine acetylation. This review details the advancements made in the study of obesity, related metabolic diseases, and protein lysine acetylation. It contributes to our understanding of the function and mechanism of protein lysine acetylation in obesity and MS and offers a fresh method for treating these diseases.

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蛋白质赖氨酸乙酰化在肥胖和代谢综合征发病和治疗中的作用。

综述目的：本综述旨在强调组蛋白去乙酰化酶（hdac）和赖氨酸乙酰转移酶（KATs）在肥胖个体中的已知作用，更好地了解hdac和KATs酶在肥胖和相关代谢紊乱中的作用。最近发现：许多细胞活动，包括DNA复制、DNA修复、细胞周期调节、RNA剪接、信号传递、代谢功能、蛋白质稳定性、运输和转录调节，都受到赖氨酸乙酰化的影响。蛋白质赖氨酸乙酰化有几个目的，它不仅有助于与肥胖有关的代谢紊乱的发展，而且还有望用于治疗方法。目前的研究表明hdac和KATs控制赖氨酸乙酰化。本文综述了肥胖、相关代谢疾病和蛋白质赖氨酸乙酰化的研究进展。这有助于我们了解蛋白质赖氨酸乙酰化在肥胖和多发性硬化症中的作用和机制，并为这些疾病的治疗提供了新的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Obesity Reports Medicine-General Medicine

CiteScore

16.40

自引率

1.10%

发文量

期刊介绍： The main objective of Current Obesity Reports is to provide expert review articles on recent advancements in the interdisciplinary field of obesity research. Our aim is to offer clear, insightful, and balanced contributions that will benefit all individuals involved in the treatment and prevention of obesity, as well as related conditions such as cardiovascular diseases, endocrine disorders, gynecological issues, cancer, mental health, respiratory complications, and rheumatological diseases. We strive to redefine the way knowledge is expressed and provide organized content for the benefit of our readership.