Effect of Customized Corneal Crosslinking on Patients With Pellucid Marginal Degeneration.

IF 1.9 3区医学 Q2 OPHTHALMOLOGY

Cornea Pub Date : 2025-03-12 DOI:10.1097/ICO.0000000000003858

Elina M Utti, Kari M Krootila

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引用次数: 0

Abstract

Purpose: To evaluate the effect of customized corneal crosslinking on pellucid marginal degeneration (PMD).

Methods: Twenty-eight eyes with PMD were included. Fifteen eyes were treated with customized corneal crosslinking at Helsinki University Eye Hospital. Three treatment zones with different ultraviolet energy levels were planned according to corneal tomography, focusing on the inferior part of the cornea. The control group consisted of 13 conventionally crosslinked eyes. Visual acuity, refraction, and corneal tomography were obtained preoperatively and at 1 month, 6 months, and 1 year after treatment.

Results: Corneal tomography showed stability and visual acuity improvement after customized crosslinking in all but 1 patient with a 1-year follow-up. Mean change in logMAR visual acuity was -0.15 (P = 0.02). However, the improvement in Kmax was not significant (-0.11D, P = 0.8). In the control group, the mean visual acuity did not change (-0.04, P = 0.44), although there were significant changes in keratometry (Kmax -0.81 D, P = 0.02 and Kavg -0.57 D, P = 0.007).

Conclusions: Customized corneal crosslinking can be safely used in patients with PMD. No clear advantages over standard crosslinking were observed in this study.

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定制角膜交联对透明边缘变性患者的影响。

目的：评价自定义角膜交联治疗透明边缘变性（PMD）的效果。方法：选取28只眼的PMD。在赫尔辛基大学眼科医院，15只眼睛接受了定制角膜交联治疗。根据角膜断层扫描，规划了三个不同紫外线能量水平的治疗区，重点是角膜的下半部。对照组由13只常规交联的眼睛组成。术前、治疗后1个月、6个月和1年分别测量视力、屈光度和角膜断层扫描。结果：在1年的随访中，除1例患者外，所有患者在定制交联后角膜断层扫描显示稳定性和视力改善。logMAR视敏度平均变化为-0.15 （P = 0.02）。然而，Kmax的改善并不显著（-0.11D, P = 0.8）。在对照组中，平均视力没有变化（-0.04,P = 0.44），但角膜度数有显著变化（Kmax -0.81 D, P = 0.02, Kavg -0.57 D, P = 0.007）。结论：定制化角膜交联可安全用于PMD患者。在这项研究中没有观察到明显优于标准交联的优势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cornea 医学-眼科学

CiteScore

5.20

自引率

10.70%

发文量

354

审稿时长

3-6 weeks

期刊介绍： For corneal specialists and for all general ophthalmologists with an interest in this exciting subspecialty, Cornea brings together the latest clinical and basic research on the cornea and the anterior segment of the eye. Each volume is peer-reviewed by Cornea''s board of world-renowned experts and fully indexed in archival format. Your subscription brings you the latest developments in your field and a growing library of valuable professional references. Sponsored by The Cornea Society which was founded as the Castroviejo Cornea Society in 1975.