Differences in Pulmonary Artery Stiffness Measured by CMR in Preterm-Born Young Adults With and Without Bronchopulmonary Dysplasia.

IF 6.5 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Circulation: Cardiovascular Imaging Pub Date : 2025-04-01 Epub Date: 2025-03-13 DOI:10.1161/CIRCIMAGING.124.017791

Wouter J van Genuchten, Jarno J Steenhorst, Gabrielle M J W van Tussenbroek, Nikki van der Velde, Lieke S Kamphuis, Irwin K M Reiss, Daphne Merkus, Willem A Helbing, Alexander Hirsch

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引用次数: 0

Abstract

Background: Very preterm-born infants are at risk for developing bronchopulmonary dysplasia (BPD), a chronic lung disease. Nowadays, the majority of these infants reach adulthood. Very preterm-born young adults are at risk for developing pulmonary arterial (PA) hypertension later in life. An early sign of PA hypertension is increased PA stiffness. This study aims to use cardiovascular magnetic resonance to compare PA stiffness using PA relative area change (RAC) and pulse wave velocity (PWV) to identify early signs for PA hypertension in young adults born very premature, with and without BPD.

Methods: Twenty preterm-born young adults with and 20 without BPD underwent cardiovascular magnetic resonance and were compared with 20 at-term-born young adults. RAC was calculated as the percentage change between the maximal and minimal areas of the PA. PWV was calculated using a method that simultaneously compares flow and area increase in the pulmonary artery during early systole.

Results: In 57 of 60 patients, PWV and RAC measurements could be performed. Preterm-born young adults with BPD showed increased PWV compared with preterm-born young adults without BPD (median [25th-75th percentile] 2.07 m/s [1.45-3.05] versus 1.61 m/s [1.18-1.85]; P=0.04) and at-term-born young adults (1.35 m/s [1.08-2.23]; P=0.04). RAC was decreased in both preterm-born young adults with (62% [56-82]; P<0.01) and without BPD (78% [67-93]; P<0.01), compared with at-term-born young adults (101% [87-122]).

Conclusions: Preterm-born young adults with BPD show increased PA stiffness as measured by PWV compared with preterm-born young adults without BPD and at-term-born young adults; RAC was decreased in both preterm-born groups compared with at-term controls. This noninvasive method of measuring PA stiffness might be a valuable tool to identify individuals at risk for early signs of PA hypertension in this population.

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CMR测量有和没有支气管肺发育不良的早产儿年轻人肺动脉硬度的差异。

背景：非常早产的婴儿有发生支气管肺发育不良（BPD）的风险，这是一种慢性肺部疾病。如今，这些婴儿中的大多数都长大成人了。非常早产的年轻人在以后的生活中有患肺动脉（PA）高血压的风险。肺动脉高压的早期征兆是肺动脉僵硬度增高。本研究旨在利用心血管磁共振技术，利用PA相对面积变化（RAC）和脉搏波速度（PWV）来比较非常早产的年轻成人（伴和不伴BPD）的PA刚度，以识别PA高血压的早期体征。方法：对20例有BPD的早产儿和20例无BPD的年轻人进行了心血管磁共振，并与20例足月出生的年轻人进行了比较。RAC计算为PA最大和最小面积之间的百分比变化。采用同时比较收缩期早期肺动脉流量和面积增加的方法计算PWV。结果：60例患者中57例可进行PWV和RAC测量。与未患BPD的早产儿相比，患有BPD的早产儿PWV增加(中位数[25 -75个百分点]2.07 m/s[1.45-3.05]对1.61 m/s [1.18-1.85]；P=0.04)和足月出生的年轻人(1.35 m/s [1.08-2.23]；P = 0.04)。两种早产儿的RAC均降低（62%）[56-82]；ppp结论：通过PWV测量，与没有BPD的早产儿和足月出生的年轻人相比，患有BPD的早产儿的PA僵硬度增加；与足月对照组相比，两组早产儿的RAC均有所下降。这种测量PA僵硬度的无创方法可能是识别这一人群中存在PA高血压早期症状的个体的有价值的工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Circulation: Cardiovascular Imaging 医学-核医学

CiteScore

6.30

自引率

2.70%

发文量

225

审稿时长

6-12 weeks

期刊介绍： Circulation: Cardiovascular Imaging, an American Heart Association journal, publishes high-quality, patient-centric articles focusing on observational studies, clinical trials, and advances in applied (translational) research. The journal features innovative, multimodality approaches to the diagnosis and risk stratification of cardiovascular disease. Modalities covered include echocardiography, cardiac computed tomography, cardiac magnetic resonance imaging and spectroscopy, magnetic resonance angiography, cardiac positron emission tomography, noninvasive assessment of vascular and endothelial function, radionuclide imaging, molecular imaging, and others. Article types considered by Circulation: Cardiovascular Imaging include Original Research, Research Letters, Advances in Cardiovascular Imaging, Clinical Implications of Molecular Imaging Research, How to Use Imaging, Translating Novel Imaging Technologies into Clinical Applications, and Cardiovascular Images.