Distinctive CD8⁺ T cell activation by antigen-presenting plasmacytoid dendritic cells compared to conventional dendritic cells.

IF 7.5 1区生物学 Q1 CELL BIOLOGY

Cell reports Pub Date : 2025-03-25 Epub Date: 2025-03-11 DOI:10.1016/j.celrep.2025.115413

Renée M van der Sluis, Juan L García-Rodríguez, Ian Helstrup Nielsen, Albert Gris-Oliver, Jennifer Becker, Bibiana Costa, M Zeeshan Chaudhry, Marvin Werner, Anders Laustsen, Jesper G Pedersen, Kristine R Gammelgaard, Trine H Mogensen, Ulrich Kalinke, Luka Cicin-Sain, Rasmus O Bak, Lasse S Kristensen, Martin R Jakobsen

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引用次数: 0

Abstract

Plasmacytoid dendritic cells (pDCs) play a pivotal role in immune responses, particularly against viral infections. pDCs exhibit diverse functions, including interferon production, cytokine secretion, and antigen presentation. Here, we investigate the antigen cross-presentation capacity of pDCs and their role in CD8⁺ T cell activation. Utilizing a culturing system with CD8⁺ T cells and autologous pDCs derived from circulating CD34⁺ hematopoietic stem and progenitor cells, we demonstrate that pDCs efficiently activate CD8⁺ T cells via cross-presentation, promoting T cell expansion and cytotoxic activity. The antigen presentation capacity of pDCs is comparable to that of monocyte-derived dendritic cells (moDCs) and myeloid dendritic cells, which are known for their efficient antigen-presentation capacity. Transcriptomic analysis reveals genetic signatures in CD8⁺ T cells activated by pDCs distinct from moDCs, suggesting different activation mechanisms. These findings underscore the importance of pDCs in antigen presentation and their contribution to CD8⁺ T cell activation.

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来源期刊

Cell reports CELL BIOLOGY-

CiteScore

13.80

自引率

1.10%

发文量

1305

审稿时长

77 days

期刊介绍： Cell Reports publishes high-quality research across the life sciences and focuses on new biological insight as its primary criterion for publication. The journal offers three primary article types: Reports, which are shorter single-point articles, research articles, which are longer and provide deeper mechanistic insights, and resources, which highlight significant technical advances or major informational datasets that contribute to biological advances. Reviews covering recent literature in emerging and active fields are also accepted. The Cell Reports Portfolio includes gold open-access journals that cover life, medical, and physical sciences, and its mission is to make cutting-edge research and methodologies available to a wide readership. The journal's professional in-house editors work closely with authors, reviewers, and the scientific advisory board, which consists of current and future leaders in their respective fields. The advisory board guides the scope, content, and quality of the journal, but editorial decisions are independently made by the in-house scientific editors of Cell Reports.