Fluoride Varnish Efficacy on the Remineralization of Early Caries Lesions in Situ.

IF 2.9 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Caries Research Pub Date : 2025-03-12 DOI:10.1159/000545160

Astrid C Valdivia-Tapia, Domenick T Zero, Frank Lippert, E Angeles Martinez-Mier, George J Eckert, Anderson T Hara

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引用次数: 0

Abstract

Introduction: In vitro studies show that fluoride varnishes (FV) differ significantly in their ability to remineralize and fluoridate enamel caries lesions, as respectively measured by surface microhardness recovery (%SMHr) and enamel fluoride-uptake (EFU). However, there is a need to confirm these findings in clinically relevant conditions.

Methods: This in situ study adopted a five-leg cross-over design. In each leg, 28 subjects wore their mandibular partial denture with two previously demineralized enamel slabs treated with one of the following FV (selected based on our previous in vitro data): Vanish™ (high-%SMHr, low-EFU), Flor-Opal® (low-%SMHr, high-EFU), Enamel-Pro® (high-%SMHr, high-EFU), PreviDent® (generic, commercial reference) or Negative control (no varnish). After three days, specimens were wrapped in gauze to allow plaque accumulation on the enamel. Toothbrushing of natural teeth was performed twice/day with F-free toothpaste. After 14 days, enamel specimens were collected and analyzed (%SMHr and EFU). Data were analyzed by ANOVA models suitable for cross-over (alpha=0.05).

Results: Vanish™ had a significantly higher %SMHr; other varnishes did not differ from each other and had higher %SMHr than the control. EFU was significantly lower for the control than for all other treatments; Flor-Opal® had significantly lower EFU than Vanish™ and PreviDent®. Neither %SMHr nor EFU in vitro data could predict in situ results, although better approximation was observed for %SMHr.

Conclusion: All tested FV could remineralize enamel; however, they presented different efficacies. Comparative clinical trials are warranted to confirm these results. Adequate in vitro tests are necessary to predict the clinical efficacy of FVs.

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氟化物清漆对早期龋原位再矿化的影响。

体外研究表明，氟化物清漆（FV）在牙釉质龋病变再矿化和氟化能力方面存在显著差异，分别通过表面显微硬度恢复（%SMHr）和牙釉质氟吸收（EFU）来测量。然而，需要在临床相关条件下证实这些发现。方法：原位研究采用五足交叉设计。在每条腿中，28名受试者佩戴下颌部分义齿，使用两个先前用以下FV（根据我们之前的体外数据选择）之一处理的脱矿牙釉质板：Vanish™（高%SMHr，低efu）， floro - opal®（低%SMHr，高efu）， enamel - pro®（高%SMHr，高efu）， PreviDent®（通用，商业参考）或阴性对照（无清漆）。三天后，用纱布包裹标本，让牙菌斑在牙釉质上积累。用不含氟的牙膏每天刷牙2次。14 d后采集牙釉质标本进行分析（%SMHr和EFU）。数据分析采用适合交叉的方差分析模型（alpha=0.05）。结果：Vanish™具有显著更高的SMHr %；其他清漆之间没有差异，其SMHr %均高于对照。对照组的EFU显著低于所有其他处理；floro - opal®的EFU明显低于Vanish™和PreviDent®。%SMHr和EFU的体外数据都不能预测原位结果，尽管%SMHr的近似性更好。结论：所有FV均能使牙釉质再矿化；然而，它们表现出不同的功效。有必要进行比较临床试验来证实这些结果。充分的体外试验是预测FVs临床疗效的必要条件。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Caries Research 医学-牙科与口腔外科

CiteScore

6.30

自引率

7.10%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Caries Research'' publishes epidemiological, clinical and laboratory studies in dental caries, erosion and related dental diseases. Some studies build on the considerable advances already made in caries prevention, e.g. through fluoride application. Some aim to improve understanding of the increasingly important problem of dental erosion and the associated tooth wear process. Others monitor the changing pattern of caries in different populations, explore improved methods of diagnosis or evaluate methods of prevention or treatment. The broad coverage of current research has given the journal an international reputation as an indispensable source for both basic scientists and clinicians engaged in understanding, investigating and preventing dental disease.