A systematic analysis and prediction of the disease burden of ischemic heart disease caused by hyperglycemia

IF 3 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes Investigation Pub Date : 2025-03-12 DOI:10.1111/jdi.70006

Jianxing Chen, Wenlinng Zeng, Dandan Dai, Yujin Tang, Yangwen Dong, Zilan Zhong, Miao Zhou, Jianhong Ye

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引用次数: 0

Abstract

Objective

This study aims to analyze the disease burden of ischemic heart disease (IHD) caused by hyperglycemia and its changing trend, and to construct a visualization platform for disease burden and forecast trends on the Shiny platform.

Materials and Methods

Using data from the 2021 Global Burden of Disease Study, we analyzed deaths and disability-adjusted life years (DALYs) due to IHD triggered by hyperglycemia, with detailed analysis by region, gender, and age. The age-period-cohort model was used to assess the impact of age, cohort, and period on age-standardized disease rates across different Socio-Demographic Index (SDI) regions, and decomposition analysis was employed to disentangle the contributions of population, aging, and epidemiological changes.

Results

In 2021, approximately 14–15% of IHD's DALYs and deaths were attributed to high fasting plasma glucose (HFPG), with a nonsignificant decrease in the annual average percentage change of DALYs. In middle, low-middle, and low SDI regions, the age-standardized mortality rates caused by HFPG are increasing, particularly among males. In high-middle and high SDI regions, the effects of aging and epidemiological changes surpass population growth, whereas in low SDI regions, population growth is the main factor. By 2050, the global Age-Standardized Mortality Rate of IHD attributed to HFPG is projected to reach 16.96. More data can be accessed by visiting the disease burden visualization platform.

Conclusion

Global HFPG-induced IHD health presents significant imbalances. In low SDI regions with larger populations and more unbalanced healthcare distribution, there is a need to strengthen the construction of medical levels.

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高血糖所致缺血性心脏病疾病负担的系统分析与预测。

目的：分析高血糖引起的缺血性心脏病（IHD）疾病负担及其变化趋势，在Shiny平台上构建疾病负担可视化平台并预测疾病负担变化趋势。材料和方法：使用来自2021年全球疾病负担研究的数据，我们分析了由高血糖引发的IHD导致的死亡和残疾调整生命年（DALYs），并按地区、性别和年龄进行了详细分析。使用年龄-时期-队列模型评估年龄、队列和时期对不同社会人口指数（SDI）区域年龄标准化发病率的影响，并采用分解分析来理清人口、老龄化和流行病学变化的贡献。结果：2021年，大约14-15%的IHD DALYs和死亡归因于高空腹血糖（HFPG）， DALYs的年平均百分比变化无显著下降。在中等、低中等和低SDI地区，HFPG引起的年龄标准化死亡率呈上升趋势，尤其是男性。在高、中、高SDI地区，老龄化和流行病学变化的影响超过了人口增长的影响，而在低SDI地区，人口增长是主要因素。到2050年，HFPG导致的IHD全球年龄标准化死亡率预计将达到16.96。通过访问疾病负担可视化平台可以获取更多数据。结论：全球hfp诱导的IHD健康存在显著的不平衡。在低SDI地区，人口较多，卫生保健分布较不平衡，需要加强医疗水平建设。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Diabetes Investigation ENDOCRINOLOGY & METABOLISM-

CiteScore

6.50

自引率

9.40%

发文量

218

审稿时长

6-12 weeks

期刊介绍： Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).