[Gender Disparities in Urolithiasis with a Special Focus on Oxalate Metabolism in the Liver].

IF 0.3 4区 医学 Q4 UROLOGY & NEPHROLOGY
Aktuelle Urologie Pub Date : 2025-04-01 Epub Date: 2025-03-12 DOI:10.1055/a-2528-0260
Roman Herout, Sven Oehlschläger
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引用次数: 0

Abstract

The incidence and prevalence of urolithiasis are increasing in industrialized countries. In particular, an increase has been observed among young adults and women. The gender gap is closing, and gender equality (1:1) with regard to urolithiasis has already been documented for the USA. Studies have demonstrated that women have higher urine pH values than men, which promotes calcium phosphate crystallization. The tendency for men to develop calcium oxalate and uric acid stones is caused by the comparatively lower urine pH values. Malnutrition combined with a lack of exercise and the occurrence of metabolic syndrome with its underlying diseases (insulin resistance, type 2 diabetes mellitus, obesity, dyslipidaemia) are discussed as the causes of the increase in upper tract stone disease in industrialized countries. Non-alcoholic fatty liver disease (NAFLD), as the most common liver disease, is considered one of the complications of metabolic syndrome, with a prevalence of approximately 23% in Germany. Animal experiments and clinical studies have demonstrated a connection between NAFLD and increased oxalate excretion in urine. Based on the literature, NAFLD represents a possible cross-gender risk factor for kidney stone formation and is therefore considered to be a generally modifiable risk factor for recurrent urolithiasis. Simple recommendations concerning NAFLD should complement the general and metabolic workup in everyday clinical practice.

[尿石症的性别差异,特别关注肝脏中的草酸代谢]。
尿石症的发病率和流行率在工业化国家呈上升趋势。特别是在年轻人和妇女中,这种情况有所增加。性别差距正在缩小,关于尿石症的性别平等(1:1)已经在美国有了记录。研究表明,女性的尿液pH值高于男性,这促进了磷酸钙的结晶。男性患草酸钙结石和尿酸结石的倾向是由于尿液pH值相对较低。营养不良加上缺乏运动和代谢综合征及其潜在疾病(胰岛素抵抗、2型糖尿病、肥胖、血脂异常)的发生被认为是工业化国家上尿路结石发病率增加的原因。非酒精性脂肪性肝病(NAFLD)作为最常见的肝脏疾病,被认为是代谢综合征的并发症之一,在德国的患病率约为23%。动物实验和临床研究表明NAFLD与尿液中草酸盐排泄增加有关。根据文献,NAFLD是肾结石形成的一个可能的跨性别危险因素,因此被认为是复发性尿石症的一个普遍可改变的危险因素。关于NAFLD的简单建议应补充日常临床实践中的一般和代谢检查。
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来源期刊
Aktuelle Urologie
Aktuelle Urologie 医学-泌尿学与肾脏学
CiteScore
0.60
自引率
33.30%
发文量
104
审稿时长
>12 weeks
期刊介绍: Die entscheidenden Ergebnisse der internationalen Forschung – für Sie auf den Punkt zusammengefasst und kritisch kommentiert Übersichtsarbeiten zu den maßgeblichen Themen der täglichen Praxis Auf dem Laufenden über die klinische Forschung durch interessante Originalien CME-Punkte sammeln mit der Rubrik "Operative Techniken" In jeder Ausgabe: Techniken wichtiger Standard-OPs – Schritt für Schritt Erstklassige OP-Skizzen mit verständlichen Erläuterungen
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