Dongxu Liu, Wenxin Hu, Zhenlin Shang, Xiaojing Pei, Jinlong Sun, Li Zhou, Yifan He, Shujing Li, Zhaohui Qu, Ze Zhang
{"title":"Preparation and Characterization of a Novel Cooling Agent With Intelligent Response Long-Term Release Effect","authors":"Dongxu Liu, Wenxin Hu, Zhenlin Shang, Xiaojing Pei, Jinlong Sun, Li Zhou, Yifan He, Shujing Li, Zhaohui Qu, Ze Zhang","doi":"10.1002/app.56764","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>Coolant, a general term for all chemical substances that produce a cooling effect without strong medicinal properties. Currently reported coolants are generally used as additives directly in food and daily chemicals. Here we pioneered a responsive nanoscale formulation to improve the application limitations of coolants. The cooling agent consists of 1,3-propanediol, high-substituted hydroxypropyl cellulose(H-HPC), and three coolants, utilizing H-HPC as the polymer shell that encapsulates and releases the coolants. It has long-lasting release properties and can be released immediately upon contact with water through the vesicle structure formed by H-HPC. The cooling agent has a particle size between 20 and 60 nm, a pH between 6.16 and 7.28, a refractive index between 1.400 and 1.500, a viscosity between 1500 and 3000 mPa s, and a good stability without precipitation and delamination after centrifugation. Meanwhile, the cold stimulation neuron test shows the excellent performance of longer duration and better effect than menthol cooling sensation. Its good formulation application shows a better application prospect in cosmetics and light chemical industry.</p>\n </div>","PeriodicalId":183,"journal":{"name":"Journal of Applied Polymer Science","volume":"142 16","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Applied Polymer Science","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/app.56764","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}
引用次数: 0
Abstract
Coolant, a general term for all chemical substances that produce a cooling effect without strong medicinal properties. Currently reported coolants are generally used as additives directly in food and daily chemicals. Here we pioneered a responsive nanoscale formulation to improve the application limitations of coolants. The cooling agent consists of 1,3-propanediol, high-substituted hydroxypropyl cellulose(H-HPC), and three coolants, utilizing H-HPC as the polymer shell that encapsulates and releases the coolants. It has long-lasting release properties and can be released immediately upon contact with water through the vesicle structure formed by H-HPC. The cooling agent has a particle size between 20 and 60 nm, a pH between 6.16 and 7.28, a refractive index between 1.400 and 1.500, a viscosity between 1500 and 3000 mPa s, and a good stability without precipitation and delamination after centrifugation. Meanwhile, the cold stimulation neuron test shows the excellent performance of longer duration and better effect than menthol cooling sensation. Its good formulation application shows a better application prospect in cosmetics and light chemical industry.
期刊介绍:
The Journal of Applied Polymer Science is the largest peer-reviewed publication in polymers, #3 by total citations, and features results with real-world impact on membranes, polysaccharides, and much more.