D. M. Hushpulian, S. V. Nikulin, A. A. Zakharyants, S. S. Savin, V. I. Tishkov
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引用次数: 0
Abstract
The role of the microbiota in maintaining human health and the current state of research on the human microbiome, with a focus on the development and prospects for the use of modern methodological approaches, such as the “gut-on-a-chip” technology, are described in this review. The relationship between the microbiome and metabolomics is discussed, as are the main results of international projects on the human microbiome. The limitations of both cultural and purely genetic (metagenomics) approaches for studying the microbiota bank are highlighted. The central focus is on comparison of different gut models. Arguments in favor of a microfluidic biochip approach are presented. Finally, the regulatory aspects of the practical implementation of microarrays in drug development and personalized medicine are discussed briefly.
期刊介绍：
Applied Biochemistry and Microbiology is an international peer reviewed journal that publishes original articles on biochemistry and microbiology that have or may have practical applications. The studies include: enzymes and mechanisms of enzymatic reactions, biosynthesis of low and high molecular physiologically active compounds; the studies of their structure and properties; biogenesis and pathways of their regulation; metabolism of producers of biologically active compounds, biocatalysis in organic synthesis, applied genetics of microorganisms, applied enzymology; protein and metabolic engineering, biochemical bases of phytoimmunity, applied aspects of biochemical and immunochemical analysis; biodegradation of xenobiotics; biosensors; biomedical research (without clinical studies). Along with experimental works, the journal publishes descriptions of novel research techniques and reviews on selected topics.
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