Highly emissive boron-doped g-C3N4-glycolchitosan probe with ultralong stability and its application in sensitive nortriptyline monitoring

IF 2.6 4区材料科学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Journal of Nanoparticle Research Pub Date : 2025-03-13 DOI:10.1007/s11051-025-06278-2

Chao He, Shengcun Chen, Min Zhang, Xing Zhang, Jie Zheng, Lei Lin

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引用次数: 0

Abstract

Antidepressant abuse has become a growing concern due to their bioaccumulation and potential drug resistance in the environment. Developing smart sensing platforms for antidepressant drug identification could monitor their contamination situation in time. Here, a novel boron-doped g-C₃N₄-glycolchitosan composite (BCNP-GC) was synthesized with high fluorescence emission and ultralong water stability. The electron-deficient boron atom greatly improves the fluorescence response of the composite, while the encapsulation of glycol-chitosan (GC) further enhances its water stability. The designed BCNP-GC could serve as a highly efficient fluorescent probe for the rapid and sensitive detection of nortriptyline (NOT), a typical antidepressant drug in the environment, via internal filtration effect and dynamic quenching effect. It is expected that this strategy can be extended to the fabrication of a variety of nitrogenous carbon-based tricyclic antidepressant monitoring systems with more customized functionalities.

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高发射硼掺杂g- c3n4 -糖基壳聚糖超长稳定性探针及其在去甲替林敏感监测中的应用

由于抗抑郁药在环境中的生物蓄积性和潜在的耐药性，其滥用已成为人们日益关注的问题。开发抗抑郁药物识别智能传感平台，及时监测其污染情况。本文合成了一种新型的硼掺杂g- c3n4 -糖基壳聚糖复合材料（BCNP-GC），具有高荧光发射和超长水稳定性。缺电子硼原子大大提高了复合材料的荧光响应，而乙二醇-壳聚糖（GC）的包封进一步增强了其水稳定性。所设计的BCNP-GC可作为一种高效荧光探针，利用内过滤效应和动态猝灭效应，对环境中典型抗抑郁药物去甲替林（NOT）进行快速、灵敏的检测。预计这一策略可以扩展到制造各种具有更多定制功能的氮碳基三环抗抑郁药监测系统。

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来源期刊

Journal of Nanoparticle Research 工程技术-材料科学：综合

CiteScore

4.40

自引率

4.00%

发文量

198

审稿时长

3.9 months

期刊介绍： The objective of the Journal of Nanoparticle Research is to disseminate knowledge of the physical, chemical and biological phenomena and processes in structures that have at least one lengthscale ranging from molecular to approximately 100 nm (or submicron in some situations), and exhibit improved and novel properties that are a direct result of their small size. Nanoparticle research is a key component of nanoscience, nanoengineering and nanotechnology. The focus of the Journal is on the specific concepts, properties, phenomena, and processes related to particles, tubes, layers, macromolecules, clusters and other finite structures of the nanoscale size range. Synthesis, assembly, transport, reactivity, and stability of such structures are considered. Development of in-situ and ex-situ instrumentation for characterization of nanoparticles and their interfaces should be based on new principles for probing properties and phenomena not well understood at the nanometer scale. Modeling and simulation may include atom-based quantum mechanics; molecular dynamics; single-particle, multi-body and continuum based models; fractals; other methods suitable for modeling particle synthesis, assembling and interaction processes. Realization and application of systems, structures and devices with novel functions obtained via precursor nanoparticles is emphasized. Approaches may include gas-, liquid-, solid-, and vacuum-based processes, size reduction, chemical- and bio-self assembly. Contributions include utilization of nanoparticle systems for enhancing a phenomenon or process and particle assembling into hierarchical structures, as well as formulation and the administration of drugs. Synergistic approaches originating from different disciplines and technologies, and interaction between the research providers and users in this field, are encouraged.