Implementing an online-delivered exercise program for childhood cancer survivors: A hybrid effectiveness-implementation protocol for the MERRIER study

David Mizrahi , Alexandra Martiniuk , Laurence Hibbert , Dinisha Govender , Tora Sibbald , Richard Mitchell , Natalia Millard , Lauren Ha , Damian Ragusa , Kylie Brown , Ben Smith
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引用次数: 0

Abstract

Background

Physical activity levels are low in childhood cancer survivors. Structured physical activity programs are not routinely provided, despite being safe and beneficial for improving physical and psychological health. Innovative health promotion programs delivered online may allow families to receive equitable health support, which may foster survivors to improve their health.

Aims

To determine implementation factors of an online exercise program recruited through a community organization, and effectiveness on physical activity levels and self-efficacy for childhood cancer survivors.

Methods and analysis

The MERRIER study is a type-1 hybrid effectiveness-implementation. Sixty children (5–18 years old) who have completed treatment for any cancer type will be enrolled between March 2025 and June 2026. Participants will be randomised (stratified by age, cancer type and sex) 1:1 to 3-months multimodal exercise or control group. The intervention group will receive five online consultations with an Accredited Exercise Physiologist to provide behaviour counselling, and prescribe an individualised aerobic, resistance and balance exercise program at low-moderate intensity. The RE-AIM framework will assess reach (e.g. recruitment rate), effectiveness (e.g. physical activity levels), adoption (e.g. qualitative interviews), implementation (e.g. exercise adherence), and maintenance (e.g. self-efficacy at follow-up). Physical function and patient-reported outcomes will be assessed at baseline (T0), post-intervention (T1; week 12) and follow-up (T2, week 24). An Axivity AX3 accelerometer will measure physical activity over five-days at T0/T1.

Implications

If effective, we aim to collaborate with community organisations, who are well placed to implement similar programs to childhood cancer survivors.

Ethics

The study was approved by The University of Sydney Health Research Ethics Committee (2024/HE000391).

Trial registration

ACTRN12624000604505p.
为儿童癌症幸存者实施在线运动项目:MERRIER研究的混合效果-实施方案
儿童癌症幸存者的体育活动水平较低。尽管有组织的体育活动项目对改善身心健康是安全和有益的,但并没有常规提供。网上提供的创新健康促进计划可以让家庭获得公平的健康支持,这可能会促进幸存者改善他们的健康。目的确定通过社区组织招募的在线锻炼计划的实施因素,以及对儿童癌症幸存者的身体活动水平和自我效能的有效性。方法与分析MERRIER研究是一种1型混合有效性-实施。在2025年3月至2026年6月期间,60名完成任何癌症治疗的儿童(5-18岁)将被纳入研究。参与者将被随机分配(按年龄、癌症类型和性别分层)1:1至3个月多模式运动组或对照组。干预组将接受五次由认可运动生理学家提供的在线咨询,以提供行为咨询,并开出个体化的低-中等强度有氧、阻力和平衡运动计划。RE-AIM框架将评估覆盖面(如招聘率)、有效性(如身体活动水平)、采用(如定性访谈)、实施(如坚持锻炼)和维持(如随访时的自我效能)。身体功能和患者报告的结果将在基线(T0)、干预后(T1;第12周)和随访(T2,第24周)。Axivity AX3加速度计将在T0/T1时测量5天内的身体活动。如果有效,我们的目标是与社区组织合作,他们有能力为儿童癌症幸存者实施类似的计划。本研究已获得悉尼大学健康研究伦理委员会(2024/HE000391)的批准。registrationACTRN12624000604505p审判。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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