Risk factors for precocious puberty: A systematic review and meta‑analysis

IF 3.4 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Psychoneuroendocrinology Pub Date : 2025-03-10 DOI:10.1016/j.psyneuen.2025.107427

Ya Wang , Hao Gou , Junjun Guo

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引用次数: 0

Abstract

Purpose

Precocious puberty (PP) typically refers to the initiation of puberty prior to the age of eight in females and before the age of nine in males. The objective of this systematic review and meta-analysis is to pinpoint the risk factors linked to PP, thereby facilitating early diagnosis and timely intervention for individuals at high risk.

Methods

A thorough search was carried out in the Cochrane Library, PubMed, and Embase databases up to November 10, 2024. The eligible studies comprised participants diagnosed with PP in the exposure group and participants without PP in the control group. The odds ratio (OR) and weighted mean difference (WMD) with 95 % confidence interval (CI) were computed using a random-effects model.

Results

Out of 653 initially identified papers, 13 studies involving 15 cohorts were ultimately included. The mate-analysis findings indicated significant associations between several factors and the incidence of PP: BMI, maternal menarche age, and duration of breastfeeding. These three factors are significantly associated with the presence of pp: estrogen (E2) levels, follicle-stimulating hormone (FSH) levels, luteinizing hormone (LH) levels.

Conclusion

The occurrence of PP is strongly associated with several factors including BMI, maternal menarche age, and breastfeeding duration. The presence of PP is associated with three factors including E2, LH, FSH.

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来源期刊

Psychoneuroendocrinology 医学-精神病学

CiteScore

7.40

自引率

8.10%

发文量

268

审稿时长

66 days

期刊介绍： Psychoneuroendocrinology publishes papers dealing with the interrelated disciplines of psychology, neurobiology, endocrinology, immunology, neurology, and psychiatry, with an emphasis on multidisciplinary studies aiming at integrating these disciplines in terms of either basic research or clinical implications. One of the main goals is to understand how a variety of psychobiological factors interact in the expression of the stress response as it relates to the development and/or maintenance of neuropsychiatric illnesses.