Impact of preoperative hyperuricemia on the prognosis of patients with acute type A aortic dissection

IF 2.5 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

IJC Heart and Vasculature Pub Date : 2025-03-12 DOI:10.1016/j.ijcha.2025.101646

Songhao Jia , Maozhou Wang , Meili Wang , Wei Luo , Yuyong Liu , Wenjian Jiang , Hongjia Zhang

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引用次数: 0

Abstract

Background

The mortality of patients with acute type A aortic dissection remains high, and it is imperative to explore the risk factors that affect patient prognosis.

Methods and results

485 patients with acute type A aortic dissection who underwent surgery were included in our study. Based on preoperative serum uric acid tests, the patients were divided into two groups. After adjusting baseline data (SMD < 0.1), the 30-day mortality (19.4 % vs 6.2 %, P < 0.001) in the hyperuricemia group were significantly higher. Univariate and multivariate COX regression revealed that hyperuricemia was an independent risk factor for 30-day mortality in patients (HR, 2.2; P = 0.016). In subgroup analysis, the trend of increased mortality in the hyperuricemia group was consistent. In a median follow-up time of 6.2 years, Landmark analysis showed that the mortality of the hyperuricemia group mainly increased significantly within 1 month after surgery (Log-rank P < 0.001), and there was no significant difference after 1 month (Log-rank P = 0.506). Through restricted cubic spline, it was found that the risk of death gradually increases with preoperative blood uric acid levels above 330 μmol/L.

Conclusion

Preoperative hyperuricemia was an independent risk factor for early mortality in patients with acute type A aortic dissection, but it did not affect the mid-term survival in patients who survived the early postoperative period.

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来源期刊

IJC Heart and Vasculature Medicine-Cardiology and Cardiovascular Medicine

CiteScore

4.90

自引率

10.30%

发文量

216

审稿时长

56 days

期刊介绍： IJC Heart & Vasculature is an online-only, open-access journal dedicated to publishing original articles and reviews (also Editorials and Letters to the Editor) which report on structural and functional cardiovascular pathology, with an emphasis on imaging and disease pathophysiology. Articles must be authentic, educational, clinically relevant, and original in their content and scientific approach. IJC Heart & Vasculature requires the highest standards of scientific integrity in order to promote reliable, reproducible and verifiable research findings. All authors are advised to consult the Principles of Ethical Publishing in the International Journal of Cardiology before submitting a manuscript. Submission of a manuscript to this journal gives the publisher the right to publish that paper if it is accepted. Manuscripts may be edited to improve clarity and expression.