Impact of rs3077 (HLA-DPA1 gene) on chronic hepatitis B virus carriage in Cotonou

IF 2.7 Q2 MULTIDISCIPLINARY SCIENCES

Scientific African Pub Date : 2025-03-05 DOI:10.1016/j.sciaf.2025.e02628

Maurel Laleye , Yanique Goussanou , Simon Azonbakin , Marius Adjagba , Arnaud Agbanlinsou , Godwin Soglo , Max Zinsou Debaly , Jean Sehonou , Anatole Laleye , Tomabu Adjobimey

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Abstract

Introduction

Hepatitis B Virus (HBV) is a major global health concern, particularly in sub-Saharan Africa, where infection rates are notably high. Despite this, data on the host genetic contributors to HBV infection, such as the single nucleotide polymorphism rs3077 (HLA-DPA1 gene), are unavailable in this region.

Objective

To contribute to closing this gap, the present study explored the association between rs3077 and chronic hepatitis B virus (HBV) carriage.

Method

We used a cross-sectional study design, incorporating both descriptive analyses of chronic HBV carriers and analytical assays for rs3077 genotyping. The study included 48 melanoderma subjects with chronic HBV from the hepato-gastroenterology department of CNHU Hospital. These were matched by age and sex with 49 HBV-negative control subjects, selected from blood donors at the Atlantic-Littoral section of the Blood Donor Agency (ANTS). Both cases and controls underwent RT-PCR genotyping.

Results

The average age of chronic HBV carriers was 41.21±12.34 years, with the most prevalent age group being 31 to 43 years, accounting for 33.33% of the population. Considering potential transmission modes, the T allele was identified as a protective factor in the dominant model (Odds Ratio [OR] 0.046; 95% Confidence Interval [CI] 0.005 - 0.136). Conversely, the C allele was found to be a risk factor in both recessive (OR 47.162; 95% CI 6.754 - 203.063) and codominant models (OR 49.782; 95% CI 7.218 - 213.609).

Conclusion

This study reveals that the C and T alleles of rs3077 have distinct roles in chronic hepatitis B virus carriage among individuals in Cotonou. Specifically, the C allele seems to be a risk factor, while the T allele appears to confer a protective effect. This finding emphasizes the importance of host genetic variation in HBV susceptibility and provides valuable insights for future research and potential targeted healthcare strategies in regions with high HBV prevalence.

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rs3077 （HLA-DPA1基因）对科托努地区慢性乙型肝炎病毒携带的影响

乙型肝炎病毒（HBV）是一个主要的全球卫生问题，特别是在感染率特别高的撒哈拉以南非洲地区。尽管如此，宿主HBV感染遗传因素的数据，如单核苷酸多态性rs3077 （HLA-DPA1基因），在该地区是不可用的。目的探讨rs3077与慢性乙型肝炎病毒（HBV）携带之间的关系，以期弥补这一空白。方法采用横断面研究设计，结合慢性HBV携带者的描述性分析和rs3077基因分型分析。该研究纳入了48名来自CNHU医院肝消化内科的慢性HBV黑皮病患者。这些人按年龄和性别与49名hbv阴性对照者相匹配，这些对照者是从献血者机构（ANTS）大西洋沿岸地区的献血者中挑选出来的。病例和对照组均进行RT-PCR基因分型。结果慢性HBV携带者的平均年龄为41.21±12.34岁，以31 ~ 43岁年龄组为主，占总人数的33.33%。考虑到潜在的传播模式，T等位基因被确定为显性模型中的保护因子(优势比[OR] 0.046；95%置信区间[CI] 0.005 - 0.136)。相反，C等位基因在两种隐性疾病中都是危险因素(OR 47.162；95% CI 6.754 - 203.063)和共优势模型(OR 49.782；95% ci 7.218 - 213.609)。结论rs3077的C和T等位基因在科托努地区慢性乙型肝炎病毒携带者中具有不同的作用。具体来说，C等位基因似乎是一个危险因素，而T等位基因似乎具有保护作用。这一发现强调了宿主遗传变异在HBV易感性中的重要性，并为未来的研究和HBV高流行地区潜在的靶向医疗策略提供了有价值的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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