Association of HIV infection, other sexually transmitted infections or their coexistence with mpox among men who have sex with men: A national questionnaire-based study in China using propensity score matching

IF 4.7 3区医学 Q1 INFECTIOUS DISEASES

Journal of Infection and Public Health Pub Date : 2025-03-07 DOI:10.1016/j.jiph.2025.102737

Meihui Zhang , Yuxuan Wang , Yinghuan Zhang , Ying Wang , Jianyu Chen , Gang Xu , Jiechen Zhang , Fan Hu , Yong Cai

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引用次数: 0

Abstract

Background

A marked increase in mpox cases was observed in May 2022 in previously non-endemic regions. The men who have sex with men (MSM) population exhibited a disproportionately higher rate of infection.

Objectives

This study aimed to investigate the coexistence of HIV infection and other sexually transmitted infections (STIs) and their association with mpox among MSM, with validatiton conducted through a case-control study utilizing propensity score matching (PSM).

Methods

A total of 2403 eligible MSM participants were recruited for a cross-sectional study conducted across six geographically representative regions of China from October 2023 to March 2024. Data were collected via an anonymous online questionnaire. Univariable and multivariable logistic regression analyses were performed to evaluate the association between status of HIV infection and other STIs and risk of mpox. Validatiton was conducted through a case-control study employing PSM.

Results

Among the total 2403 participants, 56 (2.33 %) reported diagnosis of mpox. Taking participants negative for both HIV infection and other STIs (group 1) as reference, the adjusted ORs (95 % CIs) (p value) for mpox were 2.00 (0.60–6.65) (p = 0.256), 6.26 (2.97–13.16) (p < 0.001), and 8.72 (3.45–22.00) (p < 0.001) for those who were only positive for HIV infection (group 2), only positive for other STIs (group 3) and positive for both (group 4), respectively. In the case-control study, 53 participants from the mpox group were matched to 149 participants from the non-infection group at a ratio of 1:3. The positive association between status of HIV infection and other STIs and mpox persisted, with adjusted ORs (95 % CIs) (p value) of 1.53 (0.38–6.11) (p = 0.547), 7.01 (3.00–16.38) (p < 0.001), and 6.20 (2.21–17.43) (p < 0.001) for group 2 to group 4, respectively.

Conclusions

This study demonstrated a significant association between other STIs and the risk of mpox among MSM. HIV infection alone didn’t significantly increase the risk of mpox, while other STIs were found to be strong and robust risk factors for mpox.

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男男性行为者中HIV感染、其他性传播感染或其与m痘共存的关系：中国一项使用倾向评分匹配的全国性调查问卷研究

背景：2022年5月，在以前非流行地区观察到m痘病例显著增加。男男性行为者（MSM）人群的感染率高得不成比例。目的通过倾向评分匹配（PSM）的病例对照研究，探讨MSM人群中HIV感染和其他性传播感染（STIs）的共存情况及其与m痘的关系。方法从2023年10月至2024年3月，在中国六个地理代表性地区招募2403名符合条件的MSM参与者进行横断面研究。数据通过匿名在线问卷收集。采用单变量和多变量logistic回归分析来评估HIV感染和其他性传播感染状况与m痘风险之间的关系。通过采用PSM的病例对照研究进行验证。结果2403名参与者中，56名（2.33 %）报告了m痘的诊断。以HIV感染和其他性传播感染均阴性（1组）为参照，仅HIV感染阳性（2组）、仅其他性传播感染阳性（3组）和均阳性（4组）的mpox调整后的ORs(95 % ci) （p值）分别为2.00 (0.60-6.65)（p = 0.256）、6.26 (2.97-13.16)（p <； 0.001）和8.72 (3.45-22.00)（p <； 0.001）。在病例对照研究中，53名来自m痘组的参与者与149名来自非感染组的参与者以1:3的比例匹配。HIV感染状态与其他性传播感染和mpox之间的正相关持续存在，调整后的or(95 % ci) （p值）分别为1.53 (0.38-6.11)(p = 0.547),7.01 (3.00-16.38)（p <； 0.001）和6.20 (2.21-17.43)（p <； 0.001）。结论：本研究表明MSM中其他性传播感染与m痘风险之间存在显著关联。HIV感染本身不会显著增加m痘的风险，而其他性传播感染被发现是m痘的强而有力的危险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Infection and Public Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH -INFECTIOUS DISEASES

CiteScore

13.10

自引率

1.50%

发文量

203

审稿时长

96 days

期刊介绍： The Journal of Infection and Public Health, first official journal of the Saudi Arabian Ministry of National Guard Health Affairs, King Saud Bin Abdulaziz University for Health Sciences and the Saudi Association for Public Health, aims to be the foremost scientific, peer-reviewed journal encompassing infection prevention and control, microbiology, infectious diseases, public health and the application of healthcare epidemiology to the evaluation of health outcomes. The point of view of the journal is that infection and public health are closely intertwined and that advances in one area will have positive consequences on the other. The journal will be useful to all health professionals who are partners in the management of patients with communicable diseases, keeping them up to date. The journal is proud to have an international and diverse editorial board that will assist and facilitate the publication of articles that reflect a global view on infection control and public health, as well as emphasizing our focus on supporting the needs of public health practitioners. It is our aim to improve healthcare by reducing risk of infection and related adverse outcomes by critical review, selection, and dissemination of new and relevant information in the field of infection control, public health and infectious diseases in all healthcare settings and the community.