Synthesis and post-polymerization functionalization of bromide-terminated polyesters via 1,1,3,3-tetramethylguanidine (TMG)-promoted polyesterification for biomedical applications

IF 4.5 3区工程技术 Q1 CHEMISTRY, APPLIED

Reactive & Functional Polymers Pub Date : 2025-03-05 DOI:10.1016/j.reactfunctpolym.2025.106248

Pengfei Shan , Yupeng Qiu , Honglei Wang , Qingyue Zhang , Tingting Xiang , Wenwen Lin , Qiji Zhou , Suyang Chen , Liwen Li , Zhenyu Yan , Yangchun Ge , Yuying Xie , Zhuochao Shen , Qilun Li , Zhongyu Li , Zhihui Li

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Abstract

This study explores the synthesis of functionalized polyesters using 1,1,3,3-tetramethylguanidine (TMG)-promoted polyesterification between dicarboxylic acids and dibromides. Traditional polyesters face limitations due to a lack of functional groups, hindering their biomedical utility. The TMG-mediated method enables efficient polymerization under mild conditions, producing linear and hyperbranched polyesters with reactive bromide termini. These bromide-terminated polyesters serve as versatile precursors for post-polymerization modifications, allowing the introduction of diverse functionalities (e.g., stimuli-responsiveness, fluorescence, drug conjugation) and the creation of block copolymers, hydrogels, and polymer-drug conjugates. The platform demonstrates broad monomer compatibility, scalability, and tunability, making it promising for applications such as drug delivery, tissue engineering, and multifunctional biomaterials.

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来源期刊

Reactive & Functional Polymers 工程技术-高分子科学

CiteScore

8.90

自引率

5.90%

发文量

259

审稿时长

27 days

期刊介绍： Reactive & Functional Polymers provides a forum to disseminate original ideas, concepts and developments in the science and technology of polymers with functional groups, which impart specific chemical reactivity or physical, chemical, structural, biological, and pharmacological functionality. The scope covers organic polymers, acting for instance as reagents, catalysts, templates, ion-exchangers, selective sorbents, chelating or antimicrobial agents, drug carriers, sensors, membranes, and hydrogels. This also includes reactive cross-linkable prepolymers and high-performance thermosetting polymers, natural or degradable polymers, conducting polymers, and porous polymers. Original research articles must contain thorough molecular and material characterization data on synthesis of the above polymers in combination with their applications. Applications include but are not limited to catalysis, water or effluent treatment, separations and recovery, electronics and information storage, energy conversion, encapsulation, or adhesion.