Effects of preoperative veno-venous extracorporeal membrane oxygenation management and left atrial pressure reduction via balloon atrial septostomy on respiratory system compliance in a neonate with transposition of the great arteries with intact ventricular septum

Abstract

Background

Transposition of the great arteries with intact ventricular septum causes severe hypoxia immediately after birth. Balloon atrial septostomy is often required for oxygenation improvement, and severe cases may require veno-venous extracorporeal membrane oxygenation (VV-ECMO). This case report highlights the critical role of balloon atrial septostomy in improving respiratory system compliance and facilitating early ECMO discontinuation in a neonate with transposition of the great arteries.

Case summary

A neonate with transposition of the great arteries experienced persistent hypoxia, hypotension, and lactic acidosis, prompting VV-ECMO on the first day of life. Echocardiography revealed a restrictive atrial septal defect, and balloon atrial septostomy was performed. This resulted in increased oxygen saturation, improved respiratory system compliance (from 0.19 to 0.43 mL/cmH₂O/kg), and reduced left atrial pressure. ECMO was successfully withdrawn on day 2, which was later followed by a successful Jatene procedure.

Conclusion

Balloon atrial septostomy can significantly improve oxygenation and respiratory system compliance in patients with transposition of the great arteries, enabling rapid VV-ECMO discontinuation and informing future congenital heart disease management.