Cascade C(sp3)-H bond functionalization/cyclization reaction for the synthesis of 3,3-disubstituted oxindoles by decatungstate photocatalysis

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-03-11 DOI:10.1016/j.tet.2025.134578

Xianhe Fang , Jiaxing Lv , Shuxin Yang , Mingyu Ma , Runzhe Yang , Yi Bi

引用次数: 0

Abstract

Herein, we describe a cascade C(sp³)-H bond functionalization/cyclization reaction for the synthesis of 3,3-disubstituted oxindoles. The reaction is catalyzed by decatungstate anion under near-ultraviolet light irradiation. Functionalization of aliphatic C(sp³)−H bonds occurs efficiently through this catalytic reaction. Furthermore, the selected products exhibited inhibitory effects on LPS-induced macrophage nitric oxide release.

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.