Dual readout biosensor based on AIE-type immunomagnetic ZIF-8: From sample pretreatment to multi-residue detection

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical Pub Date : 2025-03-13 DOI:10.1016/j.snb.2025.137601

Shuai Zhang , Jincheng Xiong , Boyan Sun , Chunchao Yin , Yongjun Zheng , Xingxing Liu , Yanchen Gao , Xiaomei Wang , Sihan Wang , Haiyang Jiang

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引用次数: 0

Abstract

Emerging contaminants seriously jeopardize food safety and even human health. This study presents the formation of all-in-one aggregation-induced emission (AlE)-type immunomagnetic ZlF-8 (AlMZ) through an ultra-simple self-assembly method in an aqueous phase, successfully harnessing the functions of immuno-recognition, luminescence, and magnetism, Here, we have achieved a dual enhancement in detection efficiency rapidly enriching targets and performing a triple lateral flow immunoassay (LFlA) for ractopamine, diethylstilbestrol, and chloramphenicol within 40 minutes, The dual readout biosensor was then configured to automatically extract the color intensity values of the three test lines using a smartphone. A portable sensing platform ensures stable temperature and light intensity in non-laboratory environments, providing favorable conditions for immunological detection. This study demonstrated low detection limits of 0.11, 0.14, and 0.01ug/L for ractopamine, diethylstilbestrol, and chloramphenicol, respectively, Applications in pork and tap water showed excellent practicality and stability, with recovery rates ranging from 87.2 % to 112.7 %, emphasizing the potential for applications in food and environmental safety.

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来源期刊

Sensors and Actuators B: Chemical 工程技术-电化学

CiteScore

14.60

自引率

11.90%

发文量

1776

审稿时长

3.2 months

期刊介绍： Sensors & Actuators, B: Chemical is an international journal focused on the research and development of chemical transducers. It covers chemical sensors and biosensors, chemical actuators, and analytical microsystems. The journal is interdisciplinary, aiming to publish original works showcasing substantial advancements beyond the current state of the art in these fields, with practical applicability to solving meaningful analytical problems. Review articles are accepted by invitation from an Editor of the journal.