Design, synthesis, and biological evaluation of novel derivatives of marine natural product ammosamide B

Abstract

Plant diseases caused by plant viruses and pathogens seriously affect crop yield and quality, making prevention and control extremely difficult and posing a serious threat to human health. Marine alkaloids have novel structures and diverse biological activities, which are an important source of the development of new pesticides. In this work, ammosamide alkaloids were selected as the parent structure. A series of derivatives based on the chlorinated pyrrolo[4,3,2-de]quinoline were synthesized and evaluated for their antiviral and fungicidal activities.