Insect metamorphosis and chitin metabolism under miRNA regulation: a review with current advances

IF 3.8 1区农林科学 Q1 AGRONOMY

Pest Management Science Pub Date : 2025-03-13 DOI:10.1002/ps.8758

Ashraf Khan, Guy Smagghe, Shangwei Li, Muhammad Shakeel, Guangming Yang, Nazeer Ahmed

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Abstract

Insect metamorphosis is a complex developmental process regulated by microRNAs (miRNAs) and hormonal signaling pathways. Key genes driving insect ontogenic changes are precisely modulated by miRNAs, which interact with 20-hydroxyecdysone (20E) and juvenile hormone (JH) to coordinate developmental transitions. Over the past decade, significant progress has been made in understanding miRNA biogenesis, their regulatory roles in gene expression, and their involvement in critical biological processes, including metamorphosis and chitin metabolism. miRNAs are now recognized as essential regulators of chitin metabolism and hormonal signaling, ensuring precise control of insect development. Disrupting the expression of participating genes in hormone signaling pathways through miRNAs leads to aberrant metamorphosis and consequent lethal outcomes, highlighting their potential as targets for pest control. This review summarizes current advances in miRNA-mediated regulation of insect metamorphosis and chitin metabolism, with a focus on their interactions with 20E and JH signaling pathways. By integrating recent findings, we provide insights into the molecular mechanisms underlying miRNA function in developmental transitions and their potential applications in insect pest management strategies. © 2025 Society of Chemical Industry.

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miRNA调控下的昆虫变态与几丁质代谢研究进展

昆虫变态是一个复杂的发育过程，受microrna （mirna）和激素信号通路的调控。昆虫致个体变化的关键基因是由mirna精确调控的，mirna与20-羟基蜕皮激素（20E）和幼体激素（JH）相互作用，协调发育转变。在过去的十年中，在了解miRNA的生物发生，其在基因表达中的调节作用以及它们在关键生物过程中的参与，包括变态和几丁质代谢方面取得了重大进展。mirna现在被认为是几丁质代谢和激素信号传导的重要调节因子，确保昆虫发育的精确控制。通过mirna破坏激素信号通路中参与基因的表达会导致异常变态和随之而来的致命后果，这凸显了它们作为害虫控制靶点的潜力。本文综述了mirna介导的昆虫变态和几丁质代谢调控的最新进展，重点介绍了它们与20E和JH信号通路的相互作用。通过整合最近的研究结果，我们提供了miRNA在发育转变中的分子机制及其在害虫管理策略中的潜在应用。©2025化学工业协会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pest Management Science 农林科学-昆虫学

CiteScore

7.90

自引率

9.80%

发文量

553

审稿时长

4.8 months

期刊介绍： Pest Management Science is the international journal of research and development in crop protection and pest control. Since its launch in 1970, the journal has become the premier forum for papers on the discovery, application, and impact on the environment of products and strategies designed for pest management. Published for SCI by John Wiley & Sons Ltd.