Honey in orabase paste and triamcinolone acetonide for the treatment of atrophic/erosive oral lichen planus: a randomized, blind, controlled, clinical trial.

Abstract

Purpose: This study aimed to evaluate the clinical efficacy of an innovative preparation; honey inorabase (50% in 1:1) for treating atrophic/ erosive oral lichen planus (OLP) compared with triamcinolone acetonide 0.1% ointment.

Subjects and methods: The study involved a total of 60 patients who were randomly dividedinto three groups: Group I (honey in orabase 50%, 1:1 paste), Group II (triamcinolone acetonide 0.1% ointment), and the control group, III, (orabase paste). The primary outcome measure utilized the Visual Analogue Scale (VAS), while the secondary outcome included evaluating the clinical manifestation through an OLP reduction score assessment.

Results: Compared to Group III, Groups I and II experienced significant reductions in their VASand OLP scores. Participants in Groups I and II reported minimal to no discomfort, with Group I demonstrating the most substantial pain relief.

Conclusion: In comparison to triamcinolone acetonide 0.1% ointment and the control group,the study showed that honey in orabase 50% paste is effective in the reduction of pain and lesion size in patients with atrophic/erosive OLP. Therefore, as an alternative to utilizing the traditional triamcinolone acetonide 0.1% ointment to treat atrophic/erosive OLP, honey in orabase 50% paste may be an effective treatment option.