Sayuri Yasuda, Yoshiko Takai, Yuma Yasuda, Takanori Yamamoto, Ryo Tomita, Takeshi Iwase, Norie Nonobe, Jun Takeuchi, Taiki Kojima, Koji M Nishiguchi, Hiroki Kaneko
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Abstract
Purpose: This study aimed to investigate the effects of extraocular muscle recession performed as part of strabismus surgery on posterior retinal and choroidal blood flow.
Methods: A single-center prospective study was conducted on patients who underwent strabismus surgery. Optical coherence tomography, optical coherence tomography angiography, and laser speckle flowgraphy of the macula were performed before surgery and at one week, one month, and four months after surgery. Preoperative and postoperative ratios were calculated, and longitudinal changes in retinal blood flow, choroidal thickness, and choroidal blood flow were analyzed. Furthermore, the changes based on the types of resected muscle were examined.
Results: In total, 254 eyes from 127 patients were included. The subfoveal choroidal thickness increased significantly at one week and one month after surgery, with no significant change at four months after surgery. The choroidal blood flow increased significantly at one week after surgery, with no significant changes at one and four months after surgery. The retinal vessel density significantly decreased at one week after surgery, with no significant changes at one and four months after surgery. Analysis of groups that had various muscles excised showed no significant changes in any measurements. Choroidal thickness and blood flow were significantly correlated at one week after surgery.
Conclusions: Strabismus surgery decreased retinal blood flow but increased choroidal thickness and blood flow in the early postoperative period. Moreover, no significant changes were observed in the long term compared to the preoperative period.
Translational relevance: Strabismus surgery affects the retina and choroid in the early postoperative period but not in the long term.
期刊介绍：
Translational Vision Science & Technology (TVST), an official journal of the Association for Research in Vision and Ophthalmology (ARVO), an international organization whose purpose is to advance research worldwide into understanding the visual system and preventing, treating and curing its disorders, is an online, open access, peer-reviewed journal emphasizing multidisciplinary research that bridges the gap between basic research and clinical care. A highly qualified and diverse group of Associate Editors and Editorial Board Members is led by Editor-in-Chief Marco Zarbin, MD, PhD, FARVO.
The journal covers a broad spectrum of work, including but not limited to:
Applications of stem cell technology for regenerative medicine,
Development of new animal models of human diseases,
Tissue bioengineering,
Chemical engineering to improve virus-based gene delivery,
Nanotechnology for drug delivery,
Design and synthesis of artificial extracellular matrices,
Development of a true microsurgical operating environment,
Refining data analysis algorithms to improve in vivo imaging technology,
Results of Phase 1 clinical trials,
Reverse translational ("bedside to bench") research.
TVST seeks manuscripts from scientists and clinicians with diverse backgrounds ranging from basic chemistry to ophthalmic surgery that will advance or change the way we understand and/or treat vision-threatening diseases. TVST encourages the use of color, multimedia, hyperlinks, program code and other digital enhancements.
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