A new pyrrolopyrazine alkaloid from the fruit of Lycium chinense.

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-03-12 DOI:10.1080/10286020.2025.2475481

Hui Liu, Yu-Xin Fan, Rui-Wen Xu, Yan-Jie Zhu, Gui-Min Xue, Yan-Jun Sun, Wei-Sheng Feng, Hui Chen

引用次数: 0

Abstract

A new pyrrolopyrazine alkaloid, named lycipyrazine A (1), alone with seven known alkaloids (2-8), were isolated from the fruit of Lycium chinense. The structure of new compound 1 was determined using extensive 1D and 2D spectroscopic analyses, while its absolute configuration was determined by comparison of its experimental and calculated ECD spectra. Their α-glucosidase inhibitory activity was screened using acarbose as a positive control. Compound 4 showed strong inhibitory activity against α-glucosidase (IC₅₀ = 3.04 ± 0.38 μM). This study enriched the structural diversity of alkaloids in L. chinense and provided further clues for searching new antidiabetic agents from natural sources.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.