Lifetime classic psychedelic use and headaches: A cross-sectional study.

IF 4.5 3区医学 Q1 CLINICAL NEUROLOGY

Journal of Psychopharmacology Pub Date : 2025-03-12 DOI:10.1177/02698811251324372

Zusanna Bjurenfalk, Alva Cosmo, Otto Simonsson, Caroline Ran

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引用次数: 0

Abstract

Background: Migraine and cluster headache are two primary headache disorders for which conventional treatments are limited. Classic psychedelic substances such as lysergic acid diethylamide (LSD) and psilocybin are potentially promising new treatment candidates for these conditions.

Aims: The aim of the present study was to investigate the possible relationship between the lifetime use of classic psychedelics and frequent bad headaches in a large British cohort sample.

Methods: Using data (N = 11,419) collected in 1999-2000 as part of the 1958 British National Child Development Study, this cross-sectional study used multiple logistic regression, controlling for a range of potential confounders, to test the hypothesis that lifetime use of classic psychedelics would be associated with lower odds of having frequent bad headaches.

Results: Lifetime use of classic psychedelics was associated with 25% lower odds of having frequent bad headaches (adjusted odds ratio = 0.75, 95% CI: 0.59-0.95, p = 0.016).

Conclusions: The results of the present study add to the literature suggesting classic psychedelics as a possible future prophylactic treatment option for primary headache disorders.

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终身经典迷幻药使用与头痛：一项横断面研究。

背景：偏头痛和丛集性头痛是常规治疗有限的两种主要头痛疾病。麦角酸二乙胺（LSD）和裸盖菇素等经典致幻剂是治疗这些疾病的潜在有希望的新候选药物。目的：本研究的目的是在英国的一个大队列样本中调查终身使用经典迷幻药和频繁头痛之间的可能关系。方法：使用收集于1999-2000年的数据（N = 11,419），作为1958年英国国家儿童发展研究的一部分，本横断面研究使用多元逻辑回归，控制一系列潜在的混杂因素，以检验终身使用经典迷幻药与频繁出现严重头痛的可能性较低相关的假设。结果：终生使用经典致幻剂与频繁出现严重头痛的几率降低25%相关（校正优势比= 0.75,95% CI: 0.59-0.95, p = 0.016）。结论：本研究的结果与文献一致，表明经典致幻剂可能是未来原发性头痛疾病的预防性治疗选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Psychopharmacology 医学-精神病学

CiteScore

8.60

自引率

4.90%

发文量

126

审稿时长

3-8 weeks

期刊介绍： The Journal of Psychopharmacology is a fully peer-reviewed, international journal that publishes original research and review articles on preclinical and clinical aspects of psychopharmacology. The journal provides an essential forum for researchers and practicing clinicians on the effects of drugs on animal and human behavior, and the mechanisms underlying these effects. The Journal of Psychopharmacology is truly international in scope and readership.