The Association of the Metabolic Score for Insulin Resistance (METS-IR) with Prehypertension in Normoglycemic Individuals.

IF 2.1 Q3 ENDOCRINOLOGY & METABOLISM

International Journal of Endocrinology and Metabolism Pub Date : 2024-08-03 eCollection Date: 2024-04-01 DOI:10.5812/ijem-145894

Methaq H Alogaili, Afnan A Alsallami

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引用次数: 0

Abstract

Background: Insulin resistance is a critical first step in the development of many chronic diseases such as diabetes, hypertension, and coronary artery disease (CAD). Early recognition of changes in insulin sensitivity and subsequent glycolipid dysregulation is paramount in reversing the progression of these diseases. Since the prevalence of insulin resistance is relatively high, there is a demand for a simple, easy, and inexpensive method for its detection.

Objectives: To assess the association of metabolic score for insulin resistance (METS-IR) with prehypertension (preHTN) in normoglycemic individuals.

Methods: A cross-sectional study included two groups with normal blood glucose levels (age and sex matched, 179 adults each) with and without preHTN. Those with a history of hypertension, diabetes, CAD, or on chronic drug treatment were excluded from the study. Metabolic score for insulin resistance was calculated as Ln [(2 × FPG (mg/dL) + fasting TG (mg/dL)] × BMI (kg/m²)/Ln [HDL-c (mg/dL)].

Results: The METS-IR score was significantly higher in those with preHTN (P < 0.001). One-way ANOVA showed significant differences in BMI, TG, and HDL-c according to METS-IR quartiles. Cox regression analysis showed that METS-IR is a single independent predictor of preHTN (OR = 1.3, 95% CI 1.20, 1.34).

Conclusions: Metabolic score for insulin resistance is significantly associated with and an independent predictor of prehypertension in euglycemic people.

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正常血糖个体胰岛素抵抗代谢评分（METS-IR）与高血压前期的关系

背景：胰岛素抵抗是许多慢性疾病如糖尿病、高血压和冠状动脉疾病（CAD）发展的关键第一步。早期识别胰岛素敏感性的变化和随后的糖脂失调对逆转这些疾病的进展至关重要。由于胰岛素抵抗的患病率相对较高，因此需要一种简单、简便、廉价的检测方法。目的：评估血糖正常人群胰岛素抵抗代谢评分（METS-IR）与高血压前期（preHTN）的关系。方法：横断面研究包括两组血糖水平正常的人（年龄和性别匹配，各179名成年人），有和没有preHTN。有高血压、糖尿病、冠心病或长期药物治疗史的患者被排除在研究之外。胰岛素抵抗代谢评分计算为Ln [(2 × FPG (mg/dL) +空腹TG (mg/dL)] × BMI （kg/m²）/Ln [HDL-c (mg/dL)]。结果：preHTN组的met - ir评分明显高于preHTN组（P < 0.001）。单因素方差分析显示，根据met - ir四分位数，BMI、TG和HDL-c存在显著差异。Cox回归分析显示，met - ir是preHTN的单一独立预测因子（OR = 1.3, 95% CI 1.20, 1.34）。结论：胰岛素抵抗的代谢评分与血糖正常者高血压前期的独立预测因子显著相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Endocrinology and Metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

3.10

自引率

4.80%

发文量

期刊介绍： The aim of the International Journal of Endocrinology and Metabolism (IJEM) is to increase knowledge, stimulate research in the field of endocrinology, and promote better management of patients with endocrinological disorders. To achieve this goal, the journal publishes original research papers on human, animal and cell culture studies relevant to endocrinology.