Exposures from oil and gas development and childhood leukemia risk in Colorado: A population-based case-control study.

IF 3.7 3区医学 Q2 ONCOLOGY

Cancer Epidemiology Biomarkers & Prevention Pub Date : 2025-03-11 DOI:10.1158/1055-9965.EPI-24-1583

Lisa M McKenzie, William B Allshouse, David R Johnson, Christopher C DeVoe, Myles Cockburn, Debashis Ghosh

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引用次数: 0

Abstract

Background: Children living in upstream oil and natural gas (O&G) areas may be exposed to leukemogens and at increased risk for acute lymphocytic leukemia (ALL).

Methods: We conducted a case-control study of children born in Colorado between 1992 and 2019. We matched 451 children diagnosed with ALL at age 2-9 years starting in 2002 to 2706 controls on birth month/year and Hispanic ethnicity. We estimated upstream O&G activity intensities from conception through a 10-year latency with our intensity adjusted inverse distance weighted (IA-IDW) model. We applied logistic regression models adjusted for confounders to evaluate associations between ALL and IA-IDW.

Results: For children within 5 km of an O&G well site, we observed a 62% (OR= 1.62, 95% CL:0.964, 2.62), 84% (OR = 1.84, 95% CL: 1.35 -2.48) and 100% (OR = 2.00, 95% CL: 1.14 -3.37) increase in ALL risk for low, medium, and high IA-IDW groups, compared to the referent group. Within 13 km, we observed a 59% (OR= 1.59, 95% CL:1.03, 2.37), 40% (OR = 1.40, 95% CL: 1.09 -1.80) and 164% (OR = 2.64, 95% CL: 1.80 -3.86) increase in ALL risk for low, medium, and high IA-IDW groups.

Conclusions: Colorado's children living within 13 km of O&G well sites are at increased risk for ALL, with children within 5 km bearing the greatest risk. Current setbacks between O&G well sites and residences may not be sufficient to protect the health of these children.

Impact: Our results can be applied to policies to reduce childhood leukemogen exposures.

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科罗拉多州石油和天然气开发暴露与儿童白血病风险：一项基于人群的病例对照研究

背景：生活在上游石油和天然气（O&G）地区的儿童可能暴露于白血病原，并且患急性淋巴细胞白血病（ALL）的风险增加。方法：我们对1992年至2019年在科罗拉多州出生的儿童进行了病例对照研究。从2002年开始，我们将451名2-9岁诊断为ALL的儿童与2706名出生月份/年份和西班牙裔对照进行了匹配。通过强度调整逆距离加权（IA-IDW）模型，我们估计了上游油气活动强度从概念到10年的潜伏期。我们应用经混杂因素调整的逻辑回归模型来评估ALL和IA-IDW之间的关联。结果：在距油气井5公里范围内的儿童中，与对照组相比，低、中、高IA-IDW组的ALL风险分别增加了62% （OR= 1.62, 95% CL:0.964, 2.62）、84% （OR= 1.84, 95% CL: 1.35 -2.48）和100% （OR= 2.00, 95% CL: 1.14 -3.37）。在13 km范围内，我们观察到低、中、高IA-IDW组ALL风险分别增加59% （OR= 1.59, 95% CL:1.03, 2.37）、40% （OR= 1.40, 95% CL: 1.09 -1.80）和164% （OR= 2.64, 95% CL: 1.80 -3.86）。结论：在科罗拉多州，居住在油气井场13公里范围内的儿童患ALL的风险增加，其中5公里范围内的儿童患ALL的风险最大。目前，油气井场和居民之间的障碍可能不足以保护这些孩子的健康。影响：我们的结果可以应用于减少儿童白血病暴露的政策。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Epidemiology Biomarkers & Prevention 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.50

自引率

2.60%

发文量

538

审稿时长

1.6 months

期刊介绍： Cancer Epidemiology, Biomarkers & Prevention publishes original peer-reviewed, population-based research on cancer etiology, prevention, surveillance, and survivorship. The following topics are of special interest: descriptive, analytical, and molecular epidemiology; biomarkers including assay development, validation, and application; chemoprevention and other types of prevention research in the context of descriptive and observational studies; the role of behavioral factors in cancer etiology and prevention; survivorship studies; risk factors; implementation science and cancer care delivery; and the science of cancer health disparities. Besides welcoming manuscripts that address individual subjects in any of the relevant disciplines, CEBP editors encourage the submission of manuscripts with a transdisciplinary approach.