Prevalence, microbiology, and outcome of peritonitis in peritoneal dialysis patients in vietnam: a multicenter study.

IF 2.2 4区 医学 Q2 UROLOGY & NEPHROLOGY
Nguyen Bach, Trinh Thi Kim Chi, Lu Cong Trung, Nguyen Hoang Bao Ngoc, Thai Pham Thi Hoa, Thao Ngoc Phuong Huynh, Truong Hoang Khai, Dang Anh Dao, Phan Xuan Tuoc, Vuong Quoc Dung
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引用次数: 0

Abstract

Background: Chronic kidney disease (CKD) is a substantial contributor to global mortality, requiring interventions like kidney transplantation and dialysis. Peritoneal dialysis (PD) has emerged as an effective dialytic modality despite the susceptibility to peritonitis. The study aimed to determine the prevalence of peritonitis among PD patients, elucidating pivotal factors affecting its occurrence, causative bacterial agents, and treatment outcomes (mortality rates, removal of the Tenckhoff catheter, and switch to hemodialysis).

Methods: A retrospective cohort study was conducted, which included patients who underwent PD between January 2019 and December 2021 at nine dialysis centers in Vietnam. The prevalence rate of peritonitis was estimated as the quotient of total peritonitis episodes and cumulative patient-years. The association of peritonitis with factors such as age, care (self-care or helper-assisted PD), comorbidities, education level was analyzed using regression analysis. Peritonitis outcomes including mortality rate, Tenckhoff catheter removal, and transitions to hemodialysis were evaluated. PD-related infections were assessed. Additionally, the causative bacterial agents and the negative culture rate were determined.

Results: A total of 691 PD patients from nine centers from the south of Vietnam were recruited for the study. Peritonitis was reported in 32.42% of the patients during the study period of 2019-2021. An increase in the number of patients reporting peritonitis was observed over the years. A significant association (p = 0.01) between peritonitis rate and level of literacy was found. The mortality rate among patients who underwent PD was 2.68%. About 16.18% of patients with peritonitis had to have the Tenckhoff catheter removed and needed to be switched to hemodialysis. Around 46.98% of the peritonitis cases were culture-positive.

Conclusion: The prevalence of peritonitis among PD patients in Vietnam increased from 2019 to 2021. Lower literacy positively correlated with peritonitis, regardless of the type of PD. The high prevalence of culture-negative peritonitis cases indicated gaps in diagnostic procedures or the presence of unusual pathogens. These outcomes highlight the need for improved education, diagnostic practices, and interventions to reduce peritonitis risks and enhance patient care in PD programs in Vietnam.

越南腹膜透析患者腹膜炎的患病率、微生物学和预后:一项多中心研究。
背景:慢性肾脏疾病(CKD)是造成全球死亡的主要原因之一,需要肾移植和透析等干预措施。腹膜透析(PD)已成为一种有效的透析方式,尽管易患腹膜炎。该研究旨在确定腹膜炎在PD患者中的患病率,阐明影响其发生的关键因素、致病细菌和治疗结果(死亡率、拔除Tenckhoff导管和转向血液透析)。方法:进行回顾性队列研究,纳入2019年1月至2021年12月在越南9个透析中心接受PD治疗的患者。腹膜炎的患病率估计为总腹膜炎发作数和累计患者年数的商数。采用回归分析分析腹膜炎与年龄、护理(自我护理或辅助PD)、合并症、文化程度等因素的相关性。评估了腹膜炎的结局,包括死亡率、Tenckhoff导管拔除和转向血液透析。评估pd相关感染。同时测定病原菌种类及阴性培养率。结果:研究共招募了来自越南南部9个中心的691名PD患者。2019-2021年研究期间,腹膜炎发生率为32.42%。近年来,报告腹膜炎的患者人数有所增加。腹膜炎发生率与文化水平有显著相关性(p = 0.01)。PD患者的死亡率为2.68%。约16.18%的腹膜炎患者需要拔除Tenckhoff导尿管,转而进行血液透析。46.98%的腹膜炎病例培养阳性。结论:2019 - 2021年,越南PD患者腹膜炎患病率有所上升。无论PD类型如何,识字率低与腹膜炎呈正相关。培养阴性腹膜炎病例的高流行率表明诊断程序的空白或不寻常病原体的存在。这些结果强调了改善教育、诊断实践和干预措施的必要性,以减少腹膜炎的风险,并加强越南PD项目的患者护理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BMC Nephrology
BMC Nephrology UROLOGY & NEPHROLOGY-
CiteScore
4.30
自引率
0.00%
发文量
375
审稿时长
3-8 weeks
期刊介绍: BMC Nephrology is an open access journal publishing original peer-reviewed research articles in all aspects of the prevention, diagnosis and management of kidney and associated disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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