Quantifying anterior segment vascular changes in thyroid eye disease using optical coherence tomography angiography.

IF 2.9 3区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

BMC Medical Imaging Pub Date : 2025-03-11 DOI:10.1186/s12880-025-01627-y

Ahmad Masoumi, Pedram Afshar, Hanieh Fakhredin, Hamidreza Ghanbari, Fateme Montazeri, Amirhossein Aghajani, Zahra Montazeriani, Pezhman Pasyar, Haniyeh Zeidabadinejad, Faezeh Moghimpour Bijani, Seyed Mohsen Rafizadeh

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引用次数: 0

Abstract

Purpose: Thyroid eye disease (TED) presents challenges in the accurate assessment of disease activity, especially concerning ocular surface manifestations. This study aims to evaluate the potential of anterior segment optical coherence tomography angiography (AS-OCTA) in quantifying vascular changes associated with TED, thereby enhancing understanding of its pathophysiology and aiding in diagnosis and management.

Methods: We conducted a cross-sectional study involving 29 TED patients and 21 healthy controls. Participants underwent comprehensive ophthalmic examination and AS-OCTA imaging of predefined regions of interest (ROI) in the nasal and temporal quadrants. Vascular metrics including vessel density (VD), vessel length density (VLD), vessel diameter index (VDI) and fractal dimension (FD) were analyzed using AS-OCTA software. Disease activity was assessed using clinical activity scores (CAS).

Results: TED patients exhibited increased VD and VLD, particularly in the temporal quadrant, compared to healthy controls. Additionally, TED patients in active disease phases demonstrated larger VDI in the nasal quadrant. Negative correlations were observed between superficial VD and disease activity scores, while positive correlations were found between deep VDI and disease activity.

Conclusion: AS-OCTA demonstrates potential in quantitatively assessing vascular changes in TED, providing valuable insights into its pathophysiology and potential implications for clinical management. Conjunctival vascular parameters might be valuable in grading the TED disease activity in the future.

Clinical trial number: Not applicable.

查看原文本刊更多论文

光学相干断层扫描血管造影定量甲状腺眼病前段血管变化。

目的：甲状腺眼病（TED）在准确评估疾病活动方面提出了挑战，特别是在眼表表现方面。本研究旨在评估前段光学相干断层扫描血管造影（AS-OCTA）在量化与TED相关的血管变化方面的潜力，从而增强对其病理生理学的理解，并帮助诊断和治疗。方法：我们对29例TED患者和21名健康对照者进行了横断面研究。参与者接受了全面的眼科检查和在鼻和颞象限预定义感兴趣区域（ROI）的AS-OCTA成像。采用AS-OCTA软件分析血管指标，包括血管密度（VD）、血管长度密度（VLD）、血管直径指数（VDI）和分形维数（FD）。使用临床活动评分（CAS）评估疾病活动性。结果：与健康对照相比，TED患者表现出VD和VLD增加，特别是在颞象限。此外，处于疾病活动期的TED患者在鼻象限表现出较大的VDI。浅表VD与疾病活动性评分呈负相关，而深VDI与疾病活动性评分呈正相关。结论：AS-OCTA显示了定量评估TED血管变化的潜力，为其病理生理学和临床管理提供了有价值的见解。结膜血管参数在未来的TED疾病活动分级中可能是有价值的。临床试验号：不适用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Medical Imaging RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

4.60

自引率

3.70%

发文量

198

审稿时长

27 weeks

期刊介绍： BMC Medical Imaging is an open access journal publishing original peer-reviewed research articles in the development, evaluation, and use of imaging techniques and image processing tools to diagnose and manage disease.