Further evidence of the host plasticity of porcine circovirus-2: detection of the virus in domestic dogs in Namibia.

IF 2.3 2区 农林科学 Q1 VETERINARY SCIENCES
Umberto Molini, Lourens de Villiers, Lauren M Coetzee, Herschelle P Green, Mari de Villiers, Siegfried Khaiseb, Giovanni Cattoli, William G Dundon, Giovanni Franzo
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引用次数: 0

Abstract

Porcine circovirus 2 (PCV-2) is a major pathogen of swine, causing significant production losses in the pig industry worldwide. Several studies have detected the virus in different species, both in asymptomatic and diseased subjects, highlighting PCV-2 host plasticity. As PCV-2 has been identified in carnivores, the present study was undertaken to investigate the susceptibility of domestic dogs to PCV-2 infection by testing archived blood samples originating from low-income rural areas in Namibia. The population was selected considering the high exposure probability to PCV-2 due to direct contact and/or feeding with raw pig meat or by-products. Thirty-eight of the samples (6.61%) tested positive for PCV-2, and the complete ORF2 of 7 strains was sequenced, revealing the presence of the three major PCV-2 genotypes (i.e. PCV-2a, -2b, and -2d). Convincing epidemiological links with other Namibian and South African strains were established for PCV-2a and PCV-2b strains, while the PCV-2d strains were part of a broader clade that included sequences of viruses collected worldwide, especially in Asia. Although PCV-2 was reported in diseased dogs, no statistically significant or robust causal association between infection and disease manifestation was demonstrated. In conclusion, PCV-2 infection has been identified in Namibian dogs, most likely due to the ingestion of contaminated meat and by-products. However, the epidemiological and clinical consequences are still unclear and further investigations are necessary. Nevertheless, the high proportion of infected dogs showing clinical signs raises concern about the potential of PCV-2's role as a relevant viral pathogen in Namibia. The use of raw meat for dog nutrition should be discouraged, considering the known risks to animal and human health through disease transmission.

猪圆环病毒-2宿主可塑性的进一步证据:在纳米比亚家狗中检测到该病毒。
猪圆环病毒2型(PCV-2)是猪的主要病原体,在世界范围内造成了重大的生猪生产损失。几项研究已经在不同物种(无症状和患病受试者)中检测到该病毒,突出了PCV-2宿主的可塑性。由于已在食肉动物中发现PCV-2,本研究通过检测来自纳米比亚低收入农村地区存档的血液样本,调查家养狗对PCV-2感染的易感性。选择该人群是考虑到由于直接接触和/或饲养生猪肉或副产品而导致PCV-2暴露的概率很高。其中38份(6.61%)标本PCV-2阳性,对7株标本进行ORF2全序列测序,发现PCV-2主要基因型(PCV-2a、-2b和-2d)存在。PCV-2a和PCV-2b毒株与其他纳米比亚和南非毒株建立了令人信服的流行病学联系,而PCV-2d毒株是一个更广泛的进化支的一部分,该进化支包括在全世界,特别是在亚洲收集的病毒序列。虽然在患病犬中报告了PCV-2,但感染与疾病表现之间没有统计学上显著或强有力的因果关系。总之,在纳米比亚狗中发现了PCV-2感染,很可能是由于摄入了受污染的肉类和副产品。然而,流行病学和临床后果尚不清楚,需要进一步调查。尽管如此,出现临床症状的受感染犬的高比例引起了人们对PCV-2在纳米比亚作为相关病毒病原体的潜在作用的关注。考虑到通过疾病传播对动物和人类健康的已知风险,应不鼓励使用生肉作为狗的营养。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BMC Veterinary Research
BMC Veterinary Research VETERINARY SCIENCES-
CiteScore
4.80
自引率
3.80%
发文量
420
审稿时长
3-6 weeks
期刊介绍: BMC Veterinary Research is an open access, peer-reviewed journal that considers articles on all aspects of veterinary science and medicine, including the epidemiology, diagnosis, prevention and treatment of medical conditions of domestic, companion, farm and wild animals, as well as the biomedical processes that underlie their health.
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