Maternal Serum Neuropilin a Prognostic Marker in Fetal Growth Restriction: A Tertiary Center Experience.

IF 0.6 Q3 MEDICINE, GENERAL & INTERNAL

Annals of African Medicine Pub Date : 2025-04-01 Epub Date: 2025-03-11 DOI:10.4103/aam.aam_289_24

Rekha Sachan, Pushpalata Sachan, Shalini Yadav, Munna Lal Patel, Wahid Ali

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引用次数: 0

Abstract

Introduction: Fetal growth restriction (FGR) is defined as a pathological decrease in the rate of fetal growth. Neuropilin-1 (NRP1) is a transmembrane glycoprotein, involved in the regulation of angiogenesis, and has emerged as a potential biomarker for various pregnancy-related complications. A recent study showed that NRP1 is downregulated in the placenta of FGR pregnancies. This study aimed to evaluate the role of NRP1 as a prognostic marker in FGR.

Methods: This was a case-control study, carried out in the department of obstetrics and gynecology in collaboration with pathology over a period of 1 year. After informed consent and ethical clearance, a total of 200 pregnant women were enrolled. FGR was defined as per Delphi criteria 2016. 100 women who had FGR, were classified into two groups, 37 had severe FGR, 63 had mild FGR, and 100 women who had appropriate for gestational age fetuses were considered controls. 2 ml venous blood sample was withdrawn and maternal serum NRP1 (sNRP1) level was measured by ELISA technique using (Elabscience) ELISA kit as per producer protocol.

Results: Severe FGR was found in 18.5% and mild FGR in 31%. On umbilical artery Doppler, mean pulsatility index (PI) and resistive index (RI) were increased in severe FGR fetuses as compared to mild FGR (PI 2.170 vs. 1.462 and RI 0.723 vs. 0.725). Mean sNRP1 level was high in severe FGR as compared to mild FGR, (1970.84 pg/ml vs. 1708.31 pg/ml) while a significant low level of sNRP1 (1080.75 pg/ml) was found in fetuses of appropriate for gestation age ( P ≤ 0.001). At the cutoff value of sNRP1 >1493 had a sensitivity of 100% and specificity of 96% for prediction of FGR ( P < 0.001).

Conclusions: Maternal serum sNRP1 has good diagnostic and prognostic value in FGR.

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母亲血清神经匹林是胎儿生长受限的预后标志物：三级中心经验。

胎儿生长受限（FGR）被定义为胎儿生长速度的病理性降低。神经匹林-1 （NRP1）是一种跨膜糖蛋白，参与血管生成的调节，并已成为各种妊娠相关并发症的潜在生物标志物。最近的一项研究表明，NRP1在FGR妊娠的胎盘中下调。本研究旨在评估NRP1作为FGR预后标志物的作用。方法：这是一项病例对照研究，在妇产科与病理学合作进行，为期1年。在知情同意和伦理审查后，共有200名孕妇被纳入研究。FGR的定义符合2016年德尔福标准。100名患有FGR的妇女被分为两组，37名患有严重FGR， 63名患有轻度FGR， 100名患有适合孕龄胎儿的妇女被认为是对照组。取静脉血2 ml，采用ELISA技术检测母体血清NRP1 （sNRP1）水平，采用Elabscience ELISA试剂盒。结果：重度FGR占18.5%，轻度FGR占31%。脐动脉多普勒显示，与轻度FGR相比，重度FGR胎儿的平均脉搏指数（PI）和阻力指数（RI）均升高（PI 2.170 vs. 1.462, RI 0.723 vs. 0.725）。与轻度FGR相比，重度FGR中sNRP1的平均水平较高（1970.84 pg/ml vs. 1708.31 pg/ml），而与胎龄相符的胎儿sNRP1的平均水平较低（1080.75 pg/ml）（P≤0.001）。在sNRP1的临界值下，>1493预测FGR的敏感性为100%，特异性为96% （P < 0.001）。结论：母体血清sNRP1对FGR有良好的诊断和预后价值。

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来源期刊

Annals of African Medicine MEDICINE, GENERAL & INTERNAL-

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0.90

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0.00%

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期刊介绍： The Annals of African Medicine is published by the Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria and the Annals of African Medicine Society. The Journal is intended to serve as a medium for the publication of research findings in the broad field of Medicine in Africa and other developing countries, and elsewhere which have relevance to Africa. It will serve as a source of information on the state of the art of Medicine in Africa, for continuing education for doctors in Africa and other developing countries, and also for the publication of meetings and conferences. The journal will publish articles I any field of Medicine and other fields which have relevance or implications for Medicine.