Time to initiation of antiretroviral therapy and its predictors among newly diagnosed HIV positive at the selected public health centers in Adama Town, Ethiopia.

IF 2.5 4区 医学 Q3 INFECTIOUS DISEASES
Yobsan Girma, Ephrem Mannekulih, Hunde Lemi, Tesfaye Getachew Charkos
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Abstract

Introduction: Antiretroviral therapy (ART) has significantly reduced HIV infections, but late initiation remains a major issue. This study aimed to identify predictors of ART initiation among newly diagnosed HIV-positive patients in Adama town.

Method: A retrospective cohort study was conducted, with 396 newly diagnosed HIV-positive patients. This study used a survival analysis approach, including Kaplan-Meier plots, the log-rank test, and the Cox proportional hazards model.

Result: The incidence rate was 152 per 1000 person-days for early initiation after HIV positive confirmed. In the adjusted model, gender, VCT test, disclosure status, having children in the home, opportunistic infections, and HIV/TB co-infections were significantly associated with time to ART initiation.

Conclusion: To enhance early ART initiation, healthcare programs should prioritize support for women patients, promote HIV serostatus disclosure, and improve access to VCT testing. Targeted interventions for those with comorbidities and support for families with children are also essential.

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埃塞俄比亚阿达马镇选定的公共卫生中心中新诊断的艾滋病毒阳性者开始抗逆转录病毒治疗的时间及其预测因素。
抗逆转录病毒治疗(ART)显著降低了艾滋病毒感染,但起步晚仍然是一个主要问题。本研究旨在确定Adama镇新诊断的hiv阳性患者开始抗逆转录病毒治疗的预测因素。方法:对396例新诊断hiv阳性患者进行回顾性队列研究。本研究采用生存分析方法,包括Kaplan-Meier图、log-rank检验和Cox比例风险模型。结果:HIV阳性确诊后早期启动的感染率为152 / 1000人日。在调整后的模型中,性别、VCT检测、信息披露状况、家中是否有儿童、机会性感染和HIV/TB合并感染与开始抗逆转录病毒治疗的时间显著相关。结论:为了提高抗逆转录病毒治疗的早期应用,卫生保健规划应优先支持女性患者,促进艾滋病毒血清状态的披露,并改善VCT检测的可及性。对有合并症的患者采取有针对性的干预措施,并为有儿童的家庭提供支持也至关重要。
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来源期刊
AIDS Research and Therapy
AIDS Research and Therapy INFECTIOUS DISEASES-
CiteScore
3.80
自引率
4.50%
发文量
51
审稿时长
16 weeks
期刊介绍: AIDS Research and Therapy publishes articles on basic science, translational, clinical, social, epidemiological, behavioral and educational sciences articles focused on the treatment and prevention of HIV/AIDS, and the search for the cure. The Journal publishes articles on novel and developing treatment strategies for AIDS as well as on the outcomes of established treatment strategies. Original research articles on animal models that form an essential part of the AIDS treatment research are also considered
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