Cellular Senescence in the Regenerative Niche Hampers Skeletal Muscle Repair.

Abstract

With the growing interest in skeletal muscle diseases, understanding the processes, factors, and treatments associated with muscle regeneration is crucial. Skeletal muscle regeneration is a complex process that largely depends on the niche composed of cell populations, such as satellite cells, and their microenvironment. Cellular senescence is associated with various physiological processes and age-related diseases and plays a significant role in the muscle regeneration niche. Deciphering senescence-associated alterations within this niche provides critical insights for developing targeted anti-aging therapies. This review synthesizes recent studies to elucidate the composition of the niche and its cell-cell interactions and outlines the effects of aging on muscle regeneration and corresponding therapeutic strategies. This review summarizes emerging findings and technologies in muscle regeneration, analyzing therapeutic potential and limitations of current approaches for age-related conditions to support research advancement.