{"title":"Oxygen enhanced plasma discharge and its application as carrier gas for high-field asymmetric ion mobility spectroscopy.","authors":"Hua Li, Yuqiao Zhang, Xiaoxia Du, Wenxiang Xiao","doi":"10.1007/s00216-025-05799-y","DOIUrl":null,"url":null,"abstract":"<p><p>This paper explores the application of a helium-oxygen mixture in gas curtain plasma ion source (GCP)-high-field asymmetric ion mobility spectroscopy (FAIMS). A gas mixture of oxygen and helium gases has been employed as the discharge gas. The experiments were conducted using 2-butanone, acetone, methanol, and ethanol as the sample under a radio frequency field strength of 20.3 kV/cm. When the flow rate of the discharge gas is fixed at 0.8 L/min and the helium oxygen mixture ratio is fixed at 7:1, the maximum ion signal can be obtained. With the flow rate of the carrier gas fixed at 1.2 L/min, using 100% oxygen as the carrier gas resulted in a 2.85-fold increase in signal intensity and a 72.67-fold improvement in resolution compared to a mixture of oxygen and nitrogen, as well as 100% nitrogen. Therefore, adding oxygen can not only improve the detection sensitivity of FAIMS, but also enhance its resolution.</p>","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":" ","pages":"2111-2120"},"PeriodicalIF":3.8000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Analytical and Bioanalytical Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1007/s00216-025-05799-y","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/11 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
引用次数: 0
Abstract
This paper explores the application of a helium-oxygen mixture in gas curtain plasma ion source (GCP)-high-field asymmetric ion mobility spectroscopy (FAIMS). A gas mixture of oxygen and helium gases has been employed as the discharge gas. The experiments were conducted using 2-butanone, acetone, methanol, and ethanol as the sample under a radio frequency field strength of 20.3 kV/cm. When the flow rate of the discharge gas is fixed at 0.8 L/min and the helium oxygen mixture ratio is fixed at 7:1, the maximum ion signal can be obtained. With the flow rate of the carrier gas fixed at 1.2 L/min, using 100% oxygen as the carrier gas resulted in a 2.85-fold increase in signal intensity and a 72.67-fold improvement in resolution compared to a mixture of oxygen and nitrogen, as well as 100% nitrogen. Therefore, adding oxygen can not only improve the detection sensitivity of FAIMS, but also enhance its resolution.
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Analytical and Bioanalytical Chemistry’s mission is the rapid publication of excellent and high-impact research articles on fundamental and applied topics of analytical and bioanalytical measurement science. Its scope is broad, and ranges from novel measurement platforms and their characterization to multidisciplinary approaches that effectively address important scientific problems. The Editors encourage submissions presenting innovative analytical research in concept, instrumentation, methods, and/or applications, including: mass spectrometry, spectroscopy, and electroanalysis; advanced separations; analytical strategies in “-omics” and imaging, bioanalysis, and sampling; miniaturized devices, medical diagnostics, sensors; analytical characterization of nano- and biomaterials; chemometrics and advanced data analysis.
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