Exceptional Near-Infrared II Organic Small Molecule Nanoagent for Photoacoustic/Photothermal Imaging-Guided Highly Efficient Therapy in Cancer.

IF 4 2区化学 Q1 BIOCHEMICAL RESEARCH METHODS

Bioconjugate Chemistry Pub Date : 2025-04-16 Epub Date: 2025-03-12 DOI:10.1021/acs.bioconjchem.5c00058

Yidong Bin, Lixian Huang, Jiangke Qin, Shulin Zhao, Jianniao Tian, Liangliang Zhang

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引用次数: 0

Abstract

Near-infrared II (NIR-II) photoacoustic (PA)/photothermal imaging-guided tumor therapy holds great promise in precision medicine for cancer treatment. This work reports on the synthesis and application of an organic small molecule nanoagent that has exceptional PA and photothermal properties in the near-infrared region. BCy-TPE was constructed by linking an NIR-II absorbing cyanine dye BCy-Cl with a twisted tetraphenylethene unit. The synthesized BCy-TPE exhibited an intense absorption peak at 1032 nm. After encapsulation into water-dispersible nanoparticles (NPs), BCy-TPE NPs exhibited two absorption peaks at 880 and 1046 nm. Notably, under 1064 nm laser excitation, BCy-TPE NPs deliver a remarkable photothermal conversion efficiency of 92%, together with superior biocompatibility, photostability, and PA/photothermal imaging capability. Moreover, after intravenous administration of BCy-TPE NPs into 4T1 tumor-bearing mice and treatment with safe-intensity (1.0 W cm^-2 and 1064 nm) laser irradiation, tumor temperature increased rapidly to 52 °C within 1 min and tumors are completely ablated after a single photothermal therapy treatment. Overall, this work offers a novel strategy to develop superb NIR-II photothermal agents for PA/photothermal imaging-guided highly efficient therapy in cancer.

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用于光声/光热成像引导的癌症高效治疗的特殊近红外II有机小分子纳米剂。

近红外II （NIR-II）光声(PA)/光热成像引导肿瘤治疗在癌症治疗的精准医学中具有很大的前景。本文报道了一种有机小分子纳米剂的合成和应用，该纳米剂在近红外区域具有优异的PA和光热性能。BCy-TPE是由NIR-II吸收型菁染料BCy-Cl与扭曲四苯乙烯单元连接而成。合成的bby - tpe在1032 nm处有很强的吸收峰。bby - tpe纳米粒子包封后，在880 nm和1046 nm处出现两个吸收峰。值得注意的是，在1064 nm激光激发下，bby - tpe NPs光热转换效率高达92%，同时具有优异的生物相容性、光稳定性和PA/光热成像能力。此外，4T1荷瘤小鼠经静脉给药BCy-TPE NPs后，采用安全强度（1.0 W cm-2, 1064 nm）激光照射，肿瘤温度在1 min内迅速升高至52℃，单次光热治疗后肿瘤完全消融。总之，这项工作为开发优异的NIR-II光热剂提供了一种新的策略，用于PA/光热成像引导下的癌症高效治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioconjugate Chemistry 生物-化学综合

CiteScore

9.00

自引率

2.10%

发文量

236

审稿时长

1.4 months

期刊介绍： Bioconjugate Chemistry invites original contributions on all research at the interface between man-made and biological materials. The mission of the journal is to communicate to advances in fields including therapeutic delivery, imaging, bionanotechnology, and synthetic biology. Bioconjugate Chemistry is intended to provide a forum for presentation of research relevant to all aspects of bioconjugates, including the preparation, properties and applications of biomolecular conjugates.