Perioperative Trends in Distress Among Cancer Patients: A Systematic Review and Meta-Analysis

IF 2.9 2区医学 Q2 ONCOLOGY

Cancer Medicine Pub Date : 2025-03-13 DOI:10.1002/cam4.70456

Dana G. Rowe, Ellen O'Callaghan, Seeley Yoo, Juliet C. Dalton, Joshua Woo, Edwin Owolo, Tara Dalton, Margaret O. Johnson, Andrea N. Goodwin, Kerri-Anne Crowell, Samantha Kaplan, Melissa M. Erickson, C. Rory Goodwin

{"title":"Perioperative Trends in Distress Among Cancer Patients: A Systematic Review and Meta-Analysis","authors":"Dana G. Rowe, Ellen O'Callaghan, Seeley Yoo, Juliet C. Dalton, Joshua Woo, Edwin Owolo, Tara Dalton, Margaret O. Johnson, Andrea N. Goodwin, Kerri-Anne Crowell, Samantha Kaplan, Melissa M. Erickson, C. Rory Goodwin","doi":"10.1002/cam4.70456","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Introduction</h3>\n \n <p>Distress is common among cancer patients, especially those undergoing surgery. However, no study has systematically analyzed distress trends in this population. The purpose of this study was to systematically review perioperative rates of distress, as well as differences across cancer types, in cancer patients undergoing surgical intervention.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>A systematic review was conducted using PubMed, EMBASE, Scopus, and APA PsycINFO (searched until July 17, 2023). Included studies were clinical studies of cancer patients undergoing surgery reporting distress measured by the National Comprehensive Cancer Network (NCCN) distress thermometer (DT). Data on study and patient characteristics, and preoperative and postoperative distress rates were extracted. Results were pooled, and overall distress rates were calculated as weighted means. Subanalysis by cancer type was performed. Three meta-analyses were conducted: (1) preoperative distress, (2) postoperative distress, and (3) change in distress.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Fifty-seven studies including 13,410 cancer patients were reviewed. Most patients were female (67.4%), White (77.8%), and married/partnered (72.2%), with an average age of 59.2 years. The most common cancers were breast (14 studies), brain (8), and colorectal (7). Weighted mean pre- and postoperative distress scores were 5.1 and 4.5, respectively. Distress remained high through 30 days postoperatively, then declined thereafter. Brain cancer patients reported the highest postoperative distress (5.1), followed by breast cancer patients (4.9).</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>The perioperative phase is a critical period of elevated distress in cancer patients. Preoperatively, patients experience moderate to severe levels of distress, which persist throughout the early postoperative phase, gradually declining from the 1-month postoperative mark onwards.</p>\n </section>\n </div>","PeriodicalId":139,"journal":{"name":"Cancer Medicine","volume":"14 6","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cam4.70456","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer Medicine","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cam4.70456","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction

Distress is common among cancer patients, especially those undergoing surgery. However, no study has systematically analyzed distress trends in this population. The purpose of this study was to systematically review perioperative rates of distress, as well as differences across cancer types, in cancer patients undergoing surgical intervention.

Methods

A systematic review was conducted using PubMed, EMBASE, Scopus, and APA PsycINFO (searched until July 17, 2023). Included studies were clinical studies of cancer patients undergoing surgery reporting distress measured by the National Comprehensive Cancer Network (NCCN) distress thermometer (DT). Data on study and patient characteristics, and preoperative and postoperative distress rates were extracted. Results were pooled, and overall distress rates were calculated as weighted means. Subanalysis by cancer type was performed. Three meta-analyses were conducted: (1) preoperative distress, (2) postoperative distress, and (3) change in distress.

Results

Fifty-seven studies including 13,410 cancer patients were reviewed. Most patients were female (67.4%), White (77.8%), and married/partnered (72.2%), with an average age of 59.2 years. The most common cancers were breast (14 studies), brain (8), and colorectal (7). Weighted mean pre- and postoperative distress scores were 5.1 and 4.5, respectively. Distress remained high through 30 days postoperatively, then declined thereafter. Brain cancer patients reported the highest postoperative distress (5.1), followed by breast cancer patients (4.9).

Conclusion

The perioperative phase is a critical period of elevated distress in cancer patients. Preoperatively, patients experience moderate to severe levels of distress, which persist throughout the early postoperative phase, gradually declining from the 1-month postoperative mark onwards.

Abstract Image

查看原文本刊更多论文

导言：在癌症患者中，尤其是接受手术的患者中，痛苦是一种常见现象。然而，还没有研究对这一人群的痛苦趋势进行过系统分析。本研究旨在系统回顾接受手术治疗的癌症患者围手术期的痛苦发生率以及不同癌症类型之间的差异。方法使用 PubMed、EMBASE、Scopus 和 APA PsycINFO 进行了系统性综述（搜索截止日期为 2023 年 7 月 17 日）。纳入的研究都是对接受手术的癌症患者进行的临床研究，这些研究报告了通过美国国立综合癌症网络（NCCN）窘迫温度计（DT）测量的窘迫程度。提取了有关研究和患者特征、术前和术后痛苦率的数据。对结果进行汇总，并以加权平均值计算总体窘迫率。按癌症类型进行了子分析。进行了三项荟萃分析：(1) 术前痛苦；(2) 术后痛苦；(3) 痛苦的变化。结果对包括 13,410 名癌症患者在内的 57 项研究进行了回顾。大多数患者为女性（67.4%）、白人（77.8%）、已婚/有伴侣者（72.2%），平均年龄为 59.2 岁。最常见的癌症是乳腺癌（14 项研究）、脑癌（8 项）和结直肠癌（7 项）。术前和术后的加权平均窘迫评分分别为 5.1 分和 4.5 分。术后 30 天内的窘迫感一直很高，之后有所下降。脑癌患者的术后不适感最高（5.1），其次是乳腺癌患者（4.9）。结论围手术期是癌症患者痛苦加剧的关键时期。术前，患者会经历中度到重度的痛苦，这种痛苦会持续到术后早期，从术后 1 个月开始逐渐减轻。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Cancer Medicine ONCOLOGY-

CiteScore

5.50

自引率

2.50%

发文量

907

审稿时长

19 weeks

期刊介绍： Cancer Medicine is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research from global biomedical researchers across the cancer sciences. The journal will consider submissions from all oncologic specialties, including, but not limited to, the following areas: Clinical Cancer Research Translational research ∙ clinical trials ∙ chemotherapy ∙ radiation therapy ∙ surgical therapy ∙ clinical observations ∙ clinical guidelines ∙ genetic consultation ∙ ethical considerations Cancer Biology: Molecular biology ∙ cellular biology ∙ molecular genetics ∙ genomics ∙ immunology ∙ epigenetics ∙ metabolic studies ∙ proteomics ∙ cytopathology ∙ carcinogenesis ∙ drug discovery and delivery. Cancer Prevention: Behavioral science ∙ psychosocial studies ∙ screening ∙ nutrition ∙ epidemiology and prevention ∙ community outreach. Bioinformatics: Gene expressions profiles ∙ gene regulation networks ∙ genome bioinformatics ∙ pathwayanalysis ∙ prognostic biomarkers. Cancer Medicine publishes original research articles, systematic reviews, meta-analyses, and research methods papers, along with invited editorials and commentaries. Original research papers must report well-conducted research with conclusions supported by the data presented in the paper.