{"title":"Efficient astaxanthin production: Advanced strategies to improve microbial fermentation","authors":"Qiang Zhou, Jiahui Yang, Wankui Jiang, Wenming Zhang, Minjiao Chen, Yujia Jiang, Fengxue Xin","doi":"10.1002/bbb.2709","DOIUrl":null,"url":null,"abstract":"<p>Astaxanthin is a very valuable chemical with strong antioxidant effects, including anti-cancer, anti-inflammatory, eye protection, and other properties. The rapid development of synthetic biology has facilitated microbial astaxanthin production, offering environmental benefits, mild reaction conditions, and alignment with consumer demand for natural compounds. Accordingly, this review introduces the latest progress in the production of astaxanthin using different microorganisms including native microbes like <i>Haematococcus pluvialis</i> and <i>Xanthophyllomyces dendrorhous</i>, as well as engineered microbes like <i>Yarrowia lipolytica</i> and <i>Escherichia coli</i>. Methods for improving astaxanthin production through fermentation process regulation and metabolic engineering are reviewed and directions for future work are proposed.</p>","PeriodicalId":55380,"journal":{"name":"Biofuels Bioproducts & Biorefining-Biofpr","volume":"19 2","pages":"469-484"},"PeriodicalIF":3.2000,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biofuels Bioproducts & Biorefining-Biofpr","FirstCategoryId":"5","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/bbb.2709","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Astaxanthin is a very valuable chemical with strong antioxidant effects, including anti-cancer, anti-inflammatory, eye protection, and other properties. The rapid development of synthetic biology has facilitated microbial astaxanthin production, offering environmental benefits, mild reaction conditions, and alignment with consumer demand for natural compounds. Accordingly, this review introduces the latest progress in the production of astaxanthin using different microorganisms including native microbes like Haematococcus pluvialis and Xanthophyllomyces dendrorhous, as well as engineered microbes like Yarrowia lipolytica and Escherichia coli. Methods for improving astaxanthin production through fermentation process regulation and metabolic engineering are reviewed and directions for future work are proposed.
期刊介绍：
Biofuels, Bioproducts and Biorefining is a vital source of information on sustainable products, fuels and energy. Examining the spectrum of international scientific research and industrial development along the entire supply chain, The journal publishes a balanced mixture of peer-reviewed critical reviews, commentary, business news highlights, policy updates and patent intelligence. Biofuels, Bioproducts and Biorefining is dedicated to fostering growth in the biorenewables sector and serving its growing interdisciplinary community by providing a unique, systems-based insight into technologies in these fields as well as their industrial development.
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