The association between gut microbiota and accelerated aging and frailty: a Mendelian randomization study

IF 3.4 3区医学 Q2 GERIATRICS & GERONTOLOGY

Aging Clinical and Experimental Research Pub Date : 2025-03-13 DOI:10.1007/s40520-025-02971-3

Zhiliang Yan, Guoyu Guan, Hanqi Jia, Hanyu Li, Sangdan Zhuoga, Songbai Zheng

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引用次数: 0

Abstract

Background

The recent observational studies have unveiled the correlation between the composition and dynamic alterations of the gut microbiome and aging; however, the causal relationship remains uncertain.

Aims

The objective of this study is to investigate the causal relationship between the gut microbiome and accelerated aging as well as frailty, from a genetic perspective.

Methods

We obtained data on the gut microbiome, intrinsic epigenetic age acceleration, and Frailty Index from published large-scale genome-wide association studies. A two-sample Mendelian randomization analysis was conducted primarily using inverse variance weighting model. We utilized the MR-Egger intercept analysis, IVW method, the Cochran Q test, and the leave-one-out analysis to assess the robustness of the results.

Results

IVW analysis indicated a potential association between Peptococcus (OR: 1.231, 95% CI 1.013–1.497, P = 0.037), Dialister (OR: 1.447, 95% CI 1.078–1.941, P = 0.014) and Subdoligranulum (OR: 1.538, 95% CI 1.047–2.257, P = 0.028) with intrinsic epigenetic age acceleration; while Prevotella 7 (OR: 0.792, 95% CI 0.672–0.935, P = 0.006) was associated with a potential protective effect. Allisonella (OR: 1.033, 95% CI 1.005–1.063, P = 0.022), Howardella (OR: 1.026, 95% CI 1.002–1.050, P = 0.031) and Eubacterium coprostanoligenes (OR: 1.037, 95% CI 1.001–1.073, P = 0.042) were associated with an increased risk of frailty; conversely, Flavonifractor (OR: 0.954, 95% CI 0.920–0.990, P = 0.012) and Victivallis (OR: 0.984, 95% CI 0.968-1.000, P = 0.049) appeared to exhibit a potential protective effect against frailty.

Conclusion

The findings of this study provide further evidence for the genetic correlation between gut microbiota and accelerated aging as well as frailty, enhancing the understanding of the role of gut microbiota in aging-related processes. However, the underlying mechanisms and potential clinical applications require further investigation before any targeted interventions can be developed.

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肠道微生物群与加速衰老和虚弱之间的关系：一项孟德尔随机研究

最近的观察性研究揭示了肠道微生物组的组成和动态变化与衰老之间的相关性；然而，因果关系仍然不确定。本研究的目的是从遗传学的角度探讨肠道微生物群与加速衰老和虚弱之间的因果关系。方法我们从已发表的大规模全基因组关联研究中获得肠道微生物组、内在表观遗传年龄加速和脆弱指数的数据。采用方差逆加权模型进行双样本孟德尔随机化分析。我们使用MR-Egger截距分析、IVW方法、Cochran Q检验和留一分析来评估结果的稳健性。结果vw分析显示，胃球菌（OR: 1.231, 95% CI 1.013 ~ 1.497, P = 0.037）、Dialister （OR: 1.447, 95% CI 1.078 ~ 1.941, P = 0.014）和多核下（OR: 1.538, 95% CI 1.047 ~ 2.257, P = 0.028）与内在表观遗传年龄加速存在潜在关联；而普雷沃特菌7 （OR: 0.792, 95% CI 0.672-0.935, P = 0.006）与潜在的保护作用相关。Allisonella （OR: 1.033, 95% CI 1.005-1.063, P = 0.022）、Howardella （OR: 1.026, 95% CI 1.002-1.050, P = 0.031）和coprostanoligene真杆菌（OR: 1.037, 95% CI 1.001-1.073, P = 0.042）与虚弱风险增加相关；相反，黄酮因子（OR: 0.954, 95% CI 0.920-0.990, P = 0.012）和维氏菌（OR: 0.984, 95% CI 0.968-1.000, P = 0.049）似乎表现出对虚弱的潜在保护作用。结论本研究结果为肠道菌群与加速衰老和虚弱之间的遗传相关性提供了进一步的证据，增强了对肠道菌群在衰老相关过程中的作用的认识。然而，在制定任何有针对性的干预措施之前，潜在的机制和潜在的临床应用需要进一步调查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Aging Clinical and Experimental Research 医学-老年医学

CiteScore

7.90

自引率

5.00%

发文量

283

审稿时长

1 months

期刊介绍： Aging clinical and experimental research offers a multidisciplinary forum on the progressing field of gerontology and geriatrics. The areas covered by the journal include: biogerontology, neurosciences, epidemiology, clinical gerontology and geriatric assessment, social, economical and behavioral gerontology. “Aging clinical and experimental research” appears bimonthly and publishes review articles, original papers and case reports.